将遗传风险纳入前列腺癌护理:对早期检测和精确瘤学的影响
Andrew E Amini1, Keyan Salari1,2,3
1Department of Urology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
JCO precision oncology
|February 27, 2024
概括
基因检测推进了前列腺癌 (PCa) 的精准医学. 遗传遗传风险,包括生殖系变异和多基因风险评分,指导PCa的检测和管理.
科学领域:
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
- 精准医学是一门精准的医学.
背景情况:
- 前列腺癌的基因检测 (PCa) 已经进步,影响了精确瘤学.
- 胚胎变异在~12%的晚期PCa患者中被发现,通常与侵袭性疾病有关.
- 多基因风险评分和家族史也为PCa风险评估提供了信息.
研究的目的:
- 通过遗传遗传风险来审查PCa的当前和新兴精确瘤学范式.
- 澄清遗传风险在早期检测和局部PCa管理中的作用.
主要方法:
- 对PCa中生殖系和体质遗传测试现有文献的综述.
- 对罕见致病变体和常见变体 (多原风险得分) 的临床实用性的分析.
- 检查家族病史在评估遗传PCa风险中的演变作用.
主要成果:
- 临床可行的生殖系变异指导PCa的治疗选择.
- 其他变种为有关主动监测,局部疗法和全身治疗的决定提供信息.
- 对常见变异及其与种族,祖先和早期检测的相互作用的不断增长的理解至关重要.
结论:
- 遗传遗传风险是现代前列腺癌护理的组成部分,从早期检测到局部疾病管理.
- 使用基因信息的精密瘤学方法正在改变PCa患者的治疗结果.
- 需要进一步的研究,才能将遗传风险评估完全纳入所有人群的临床实践.
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