冠状病毒疾病2019年 (COVID-19) 疫苗接种时间和对月经周期变化的影响
Alison Edelman1, Emily R Boniface, Victoria Male
1Department of Obstetrics and Gynecology, Oregon Health & Science University, and Oregon Health & Science University-Portland State University, School of Public Health, Portland, Oregon; the Department of Metabolism Digestion and Reproduction, Imperial College London, London, United Kingdom; Obstetrics and Gynaecology, University of Edinburgh and Chalmers Centre, Edinburgh, Scotland; Natural Cycles USA Corp, New York, New York; the Department of Obstetrics and Gynecology, University of Massachusetts Chan Medical School, Worcester, Massachusetts; and the National Institute of Public Health, Center for Population Health Research, Cuernavaca, Mexico.
在卵泡期内接种COVID-19疫苗可能会稍微延长月经周期. 在黄质阶段或未接种疫苗的个人接种疫苗时,没有显著的周期长度变化.
科学领域:
- 生殖健康 生殖健康
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 月经周期的规律性对生殖健康至关重要.
- 接种COVID-19疫苗对月经周期的影响是一个日益增长的研究领域.
- 了解潜在的循环变化可以为疫苗施用策略提供信息.
研究的目的:
- 调查月经周期 (卵泡相对黄体阶段) 中COVID-19疫苗的时间与周期长度的变化之间的关联.
- 为了比较接种疫苗的个体与未接种疫苗的对照组的周期长度变化.
主要方法:
- 利用在2021年至2022年期间从近20,000名"自然周期"应用程序的用户收集的前性月经周期跟踪数据.
- 将疫苗给药分为毛囊或质阶段,并包括一个未接种疫苗的对照组.
- 从疫苗接种前的平均值对个体内周期长度调整的初级结果进行了评估,包括对临床显著变化 (≥8天) 的分析.
主要成果:
- 在卵泡阶段接种疫苗的个体在接种第一或第二剂COVID-19疫苗后,周期长度平均增加了大约1天.
- 在质期或未接种疫苗的对照组中接种疫苗并没有导致周期长度发生显著变化.
- 在卵泡阶段接种疫苗的个体中,与形阶段或未接种疫苗的对照人群相比,观察到临床显著的周期长度变化 (≥8天) 的可能性更高 (P <.001).
结论:
- 在月经周期的卵泡期内进行的COVID-19疫苗接种与周期长度的小而暂时增加有关.
- 在月经周期内接种COVID-19疫苗的时间似乎不会对周期长度造成重大或持久的干扰.
- 这些发现有助于了解疫苗接种潜在的轻微生理反应.
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