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一个简化的蛋白质组学LC-MRM-MS试验,用于在血样本中确定apoE基因型

Deema O Qasrawi1, Abdulhameed Al-Ghabkari2, Rania M Khan1

  • 1Segal Cancer Proteomics Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Québec H3T 1E2, Canada.

Journal of proteome research
|February 27, 2024
PubMed
概括

本研究介绍了一种简化的LC-MRM-MS试验,用于精确的阿波利波蛋白E (apoE) 血基因定型. 该方法可靠地识别apoE基因型,而不需要稳定的同位素标记的内部标准,提供了有价值的诊断工具.

关键词:
阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.在 LC-MRM-MS 中.apoE 基因型的基因型亚脂蛋白 E 是一种非脂蛋白 E.

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Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...