介质流体压力对剪切波弹性学的影响:一项实验和计算研究
Ariana Cihan1, Kristyna Holko1,2, Luxi Wei3
1Institute of Biomedical Engineering and Technology, Ghent University, Ghent, Belgium.
Physics in medicine and biology
|February 27, 2024
概括
过高的间位液压 (IFP) 会使组织变硬. 剪波弹性图 (SWE) 通过剪波速度 (SWV) 测量这种刚度,提供了潜在的非侵入性IFP测量方法.
科学领域:
- 生物医学工程 生物医学工程
- 生物物理学的生物物理.
- 医疗成像医学成像
背景情况:
- 过高的间位液压 (IFP) 会导致皮质弹性组织的应力诱导硬化.
- 剪波弹性图 (SWE) 通过评估剪波速度 (SWV) 来测量组织刚度.
- IFP与组织硬化之间的生物力学联系需要进一步阐明.
研究的目的:
- 通过使用SWE,研究介质流体压力 (IFP) 和剪切波速度 (SWV) 之间的关系.
- 了解控制IFP诱导的组织硬的生物力学原理.
- 开发一种非侵入性IFP测量模型.
主要方法:
- 在使用动态IFP调制的胸组织上进行SWE实验.
- 利用有限元建模来探索材料模型 (多弹性与多高弹性) 和边界条件 (受约束与不受约束).
- 研究了几何线性和非线性对SWV-IFP关系的影响.
主要成果:
- 在实验中证明了SWV和IFP之间的显著正相关性.
- 数字模型准确地复制了在不受约束的孔状超弹性组织中的SWV-IFP关系.
- 材料非线性被确定为硬化的主要驱动因素,几何非线性起到较小的作用.
- 在压力增加和下降期间观察到明显的SWV-IFP反应,表明动态效应.
结论:
- 该研究建立了IFP和SWV之间的联系,支持SWE对IFP估计.
- 材料非线性是IFP诱导组织硬化的关键.
- 开发的模型提供了一个框架,用于SWE分析弹性组织,推进非侵入性IFP监测.
更多相关视频
12:18Magnetic Resonance Elastography Methodology for the Evaluation of Tissue Engineered Construct Growth
Published on: February 9, 2012
12.5K
04:51Author Spotlight: Characterizing Environmental Biofilm Mechanics Using Optical Coherence Elastography and its Applications in Wastewater Treatment
Published on: March 1, 2024
984
相关概念视频
Elastic Strain Energy for Shearing Stresses
186
As discussed in previous lessons, strain energy in a material is the energy stored when it is elastically deformed, a concept crucial in materials science and mechanical engineering. This energy results from the internal work done against the cohesive forces within the material. When a material undergoes shearing stress and corresponding shearing strain, the strain energy density, which is the energy stored per unit volume, is calculated. Within the elastic limit, where the stress is...
186
Ultrasound II: Endoscopic Ultrasound and FibroScan
106
Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
Endoscopic Ultrasound (EUS):
106
Shearing Strain
272
The shearing strain represents a cubic element's angular change when subjected to shearing stress. This type of stress can transform a cube into an oblique parallelepiped without influencing normal strains. The cubic element experiences a significant transformation when exposed solely to shearing stress. Its shape alters from a perfect cube into a rhomboid, clearly demonstrating the effect of shearing strain. The degree of this strain is considered positive if it reduces the angle between...
272
Newtonian Fluid: Problem Solving
222
Newtonian fluids exhibit a constant viscosity, meaning their shear stress and shear strain rate are directly proportional. This property ensures a predictable and stable response to applied forces, maintaining a linear relationship between force and flow. Examples include water, air, and light oils, consistently demonstrating this proportional behavior regardless of external conditions.
A velocity gradient forms within the fluid when a Newtonian fluid is placed between two parallel plates, with...
A velocity gradient forms within the fluid when a Newtonian fluid is placed between two parallel plates, with...
222
Sound as Pressure Waves
2.4K
Sound waves, which are longitudinal waves, can be modeled as the displacement amplitude varying as a function of the spatial and temporal coordinates. As a column of the medium is displaced, its successive columns are also displaced. As the successive displacements differ relatively, a pressure difference with the surrounding pressure is created. The gauge pressure varies across the medium.
The pressure fluctuation depends on the difference in displacements between the successive points in the...
The pressure fluctuation depends on the difference in displacements between the successive points in the...
2.4K
Problem Solving on Stress and Strain
742
Stress is a quantity that describes the magnitude of a force that causes deformation, generally defined as internal force per unit area. When forces pull on an object and cause its elongation, like the stretching of an elastic band, it is called tensile stress. When forces cause the compression of an object, it is known as compressive stress. When an object is being squeezed uniformly from all sides, like a submarine in the depths of the ocean, we call this kind of stress bulk stress (or volume...
742
