激素替代疗法和韩国女性乳腺癌发病率
Euna Choi1, Jae Kyung Lee1, Jin Kyung Baek1
1Department of Obstetrics and Gynecology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
Maturitas
|February 27, 2024
概括
自2002年以来,更年期激素治疗 (MHT) 的使用,特别是雌激素-孕激素治疗 (EPT),在韩国下降了. 尽管如此,乳腺癌发病率每年都在上升,这表明MHT不是这一趋势的重要驱动因素.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 2002年妇女健康倡议 (WHI) 的研究导致更年期荷尔蒙疗法 (MHT) 使用的全球减少.
- 尽管进行了随后的研究,但仍然存在对MHT安全性的持续担忧,特别是关于乳腺癌风险的担忧.
- 这项研究调查了韩国MHT利用趋势与乳腺癌发病率之间的相关性.
研究的目的:
- 分析韩国MHT处方模式与侵袭性乳腺癌发病率之间的关系.
- 评估从2002年到2020年使用MHT的变化.
- 评估MHT趋势对不同年龄组乳腺癌发病率的影响.
主要方法:
- 利用2002年至2020年的韩国瘤注册数据来计算侵袭性乳腺癌的发病率.
- 将女性分为两个年龄组:50岁以下和50岁以上.
- 使用国家药房数据确定MHT处方号码.
主要成果:
- 在韩国,乳腺癌发病率在2002年至2020年间从每10万女性中的34.3个上升到每10万女性中的96.4个.
- 在两个年龄组 (<50岁和>50岁) 均观察到乳腺癌发病率的每年增加,没有显著差异.
- 从2002年到2020年,雌激素治疗 (ET) 的处方减少了52.7%,雌激素-孕激素治疗 (EPT) 的处方减少了27.9%.
- 在初步下降之后,到2020年,与2002年相比,提博的处方量增加了93.6%.
结论:
- 乳腺癌发病率在所有年龄段的韩国女性中都呈现出持续的年度增长.
- 自2002年以来,ET和EPT的使用量大幅下降,EPT的使用量在2010年之后显著下降.
- 该研究得出的结论是,MHT,尤其是EPT,与韩国女性乳腺癌发病率上升没有显著关联.
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