一氧化碳释放纳米机基于内源生化反应,用于瘤治疗
Tiantian Chen1, Yu Duan1, Wenjun Dai1
1National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China.
Journal of colloid and interface science
|February 27, 2024
概括
研究人员开发了新型纳米发动机,释放一氧化碳 (CO) 并增强化学动力学治疗 (CDT) 以改善瘤治疗. 这种双重作用的方法有效地通过利用内源反应来抑制瘤的生长.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 癌症治疗 癌症治疗
背景情况:
- 单一治疗的有效性有限,缺乏选择性释放,阻碍了在瘤治疗中使用一氧化碳 (CO) 供体.
- 瘤微环境对向药物输送和治疗提出了挑战.
- 内生生化反应为开发先进的治疗策略提供了潜力.
研究的目的:
- 为多式协同瘤治疗设计释放CO的纳米电机.
- 为了利用内源反应选择性释放二氧化碳和增强治疗效果.
- 调查CO气体治疗和化学动力学治疗 (CDT) 在癌症治疗中的联合疗效.
主要方法:
- 在MIL-101上同时修改葡萄糖氧化酶 (GOx) 和5-氨基氨基氨基酸 (5-ALA),以创建MIL-GOx-ALA纳米引擎 (M-G-A NMs).
- 利用5-ALA的内源性瘤微环境反应来产生CO.
- 研究CO在线粒体功能和活性氧物种 (ROS) 生成中的作用.
- 通过ROS和通过芬顿反应的纳米运动降解产品来评估CDT的增强.
- 在体外和体内评估治疗疗效.
主要成果:
- M-G-A NMs在瘤微环境中表现出极好的生物相容性和降解.
- 释放的5-ALA成功产生了CO,诱导了线粒体ROS的产生和直接杀死瘤细胞.
- 通过ROS和纳米运动降解产品实现了增强的CDT,促进瘤细胞亡.
- 结合CO气体治疗和增强的CDT在实验模型中有效抑制了瘤生长.
结论:
- 开发的M-G-A NMs为多模式协同瘤治疗提供了一个新的平台.
- 利用内源生物化学反应可以选择性释放二氧化碳并改善治疗结果.
- 氧化碳治疗和CDT的结合显示出未来癌症治疗应用的重大前景.
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