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Updated: Jul 2, 2025

Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay PCA in Living Cells
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Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay PCA in Living Cells

Published on: March 3, 2015

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与蛋白质水平之间的比率的遗传关联检测到新的pQTL,并揭示蛋白质-蛋白质相互作用

Karsten Suhre1

  • 1Bioinformatics Core, Weill Cornell Medicine-Qatar, Education City, Doha 24144, Qatar; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA.

Cell genomics
|February 27, 2024
PubMed
概括

本研究介绍了使用英国生物库蛋白质组学数据的比例定量特征位点 (rQTL). 分析蛋白质比率揭示了生物联系,并增强了药物向开发的遗传发现.

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Probing High-density Functional Protein Microarrays to Detect Protein-protein Interactions

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相关概念视频

Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
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Protein-protein Interfaces02:04

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
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