怀孕期间母亲喘症状对孩子的行为和执行功能的影响:贝叶斯现象学方法
Syeda Fabeha Husain1, Andrea Cremaschi2, Noor Hidayatul Aini Suaini3
1Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Brain, behavior, and immunity
|February 27, 2024
概括
怀孕期间母亲喘症状与儿童的行为和执行问题增加有关,这表明母亲免疫激活的作用. 父亲的喘症状没有显示出这种关联.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 免疫学 免疫学 免疫学
背景情况:
- 怀孕期间母亲的炎症状况可能会影响后代的神经发育.
- 孕产妇免疫激活 (MIA) 假说表明妊娠期免疫失调会影响胎儿的神经发育.
- 孕产妇炎症的时间对后代的结果至关重要.
研究的目的:
- 调查孕期母亲喘症状对儿童行为和执行功能的影响.
- 为了比较母亲对父亲喘症状对儿童结果的影响.
- 探索孕产妇免疫激活在产前喘相关影响中的作用.
主要方法:
- 分析了来自新加坡成长向健康结果 (GUSTO) 队列的844个家庭.
- 父母喘症状的回顾性报告和儿童喘症状的纵向报告.
- 评估七岁儿童的行为问题和执行功能,使用通用线性和贝叶斯现象学模型.
主要成果:
- 产前喘症状的母亲的孩子表现出明显更大的行为和执行问题 (科恩d:0.43-0.75).
- 这些关联在调整孩子的喘症状和父亲喘病史后仍然存在.
- 母亲产前喘症状与内化症状和更高层次的执行功能有关,而儿童喘症状与执行功能技能有关.
结论:
- 母亲,但不是父亲,产前喘症状与不利的儿童行为和执行结果有关,支持MIA假设.
- 研究结果表明,母体免疫激活在塑造儿童神经发育方面可能发挥作用.
- 需要在更大的队列中进一步验证,以确定与MIA暴露相关的特定行为和认知概况.
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