由于磁盘位而导致的耐火性关节障碍中的英科博胺毒素A:一项前性研究

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Eduardo Freitas Ferreira¹, Alexandre Camões-Barbosa²

¹Physical and Rehabilitation Medicine Specialist, Physical and Rehabilitation Medicine Department, Hospital Professor Doutor Fernando Fonseca, Amadora, Portugal.

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概括

毒素A注射有效地减少了因盘位位而导致耐火性部疾病 (TMD) 的患者的疼痛. 当其他疗法失败时,这种治疗为管理持续的TMD症状提供了一个安全的选择.

科学领域:

神经学神经学
口腔和牙面部外科手术
疼痛管理疼痛管理

背景情况:

部疾病 (TMD) 包括关节和肌肉疾病,大约20%的患者对初始治疗没有反应.
耐火性TMD是一个重大挑战,需要对替代治疗策略进行评估.

研究的目的:

评估因盘位引起的耐火性TMD治疗中的IncobotulinumtoxinA的疗效和安全性.
在这个患者群体中,研究因科博胺毒素A对减轻疼痛和口腔开口的影响.

主要方法:

一项前性,单臂准实验性研究,涉及因椎间盘脱而被诊断为TMD的患者.
在EMG或超声波的指导下,注射IncobotulinumtoxinA (20U/肌肉) 进入肌 (masseter和pterygoideus lateralis) 中.
疼痛和最大口腔开口在基线和治疗后4,12和24周被测量.

主要成果:

观察到明显的疼痛减轻,从基线的平均值6.08/10下降到第4周的2.04/10 (p < 0.001).
在第12周 (3.18/10) 和第24周 (3.65/10) 疼痛水平仍然显著降低.
在第4周,最大的无助口腔开口从36.45毫米减少到32.29毫米 (p < 0.001).

结论:

将肉毒毒素注射到肌中似乎是治疗耐火性TMD的安全方法.
这种治疗方法在缓解因椎间盘脱而导致的TMD相关疼痛方面表现出有效性.

关键词:

肉毒毒素是一种毒素.磁盘位移的发生是因为磁盘的位移.状肌肉是状肌肉的一个组成部分.短关节疾病短关节疾病

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