与MASLD相关的饮食宏观和微量营养素:对美国国家队列数据库的分析
Mary Nemer1, Fauzia Osman2, Adnan Said3
1Department of Medicine, Gastroenterology and Hepatology. Medical College of Wisconsin, Milwaukee, WI, United States.
Annals of hepatology
|February 27, 2024
概括
代谢综合征相关的性肝病 (MASLD) 与特定的饮食模式有关. 患有MASLD的患者表现出某些微量营养素的缺乏和巨量营养素的过剩,这表明饮食起着关键作用.
科学领域:
- 营养科学 营养科学
- 肝病学 肝病学是一种肝病学.
- 公共卫生 公共卫生
背景情况:
- 代谢综合征相关的性肝病 (MASLD) 是一个日益严重的健康问题.
- 饮食因素越来越被认为是MASLD发展和进展的重要贡献者.
- 了解MASLD中的营养摄入模式对于有针对性的干预至关重要.
研究的目的:
- 为了比较MASLD和匹配的对照人群之间的宏观和微量营养素摄入量.
- 在美国人口中确定与MASLD的特定营养关联.
- 为MASLD管理指导未来的研究和临床建议.
主要方法:
- 使用了2017-2018年国家健康和营养检查调查 (NHANES) 数据集.
- 在没有其他肝病的成年人 (>18) 中使用弹性学控制衰减参数 (CAP分数>280) 定义了MASLD.
- 包括有或没有MASLD的成年人,通过过渡性弹性学 (>10kPa) 定义的晚期纤维化.
主要成果:
- 分析了1648例MASLD病例和2527例对照病例;11.4%的MASLD病例患有晚期纤维化.
- MASLD病例的BMI较高,糖尿病,高脂血症,高血压,hs-CRP和费里丁的患病率较高.
- MASLD病例显示维生素E和K摄入量较低,,热量,碳水化合物,胆固醇和和脂肪酸摄入量较高,并且更久坐.
结论:
- 微量营养素缺乏和巨量营养素过多的饮食模式与MASLD有关.
- 这些营养不平衡可能会导致MASLD的氧化应激,炎症和脂毒性.
- MASLD患者经常使用特殊饮食表明需要对饮食修改进行意识和潜在的预先咨询.
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