在接受试管婴儿的患者中,FSHR基因多态与卵巢反应差的关联:系统性审查和元分析

在接受试管婴儿的患者中,FSHR基因多态与卵巢反应差的关联:系统性审查和元分析

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Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

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Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

Published on: September 16, 2021

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Siya Hu¹, Yunnan Jing², Yiman Fu³

¹Department of Obstetrics and Gynecology, Heilongjiang University of Chinese Medicine, Harbin 150040, China.

Gene

|February 27, 2024

概括

这项元分析发现,FSHR基因rs6166 S等位基因在亚洲人群中增加了卵巢反应不良 (POR) 的风险. rs6165 T等位基因与POR风险增加有关,特别是在接受试管婴儿的高加索人群中.

科学领域:

遗传学是一个遗传学.
生殖医学生殖医学
在体外受精 (IVF)

背景情况:

不一致的研究结果将毛囊刺激激素受体 (FSHR) 基因多态性与IVF中卵巢反应不良 (POR) 的风险联系起来.
需要进行全面的元分析来澄清这些关联.

研究的目的:

调查FSHR基因多态 (rs6166和rs6165) 与POR风险之间的关联.
为了更清楚地了解影响卵巢对试管婴儿反应的遗传因素.

主要方法:

在六个电子数据库中进行了系统的文献搜索.
从24篇符合条件的文章中提取数据,并使用元分析技术进行分析.
计算了几率比率 (OR) 和95%置信区间 (CI),并使用Begg和Egger的测试来评估出版偏差.

主要成果:

rs6166多态性显著与POR风险增加有关,特别是在各种遗传模型中的亚洲人群中.
在所有评估的遗传模型中,rs6165多态性与增加的POR风险显著相关,特别是在高加索人群中.
在2206例病例和3897例对照中分析了rs6166,而rs6165涉及444例病例和875例对照.

结论:

rs6166 S等位基因是POR的重要风险因素,在亚洲人群中具有明显的影响.
此外,rs6165 T基因基因也与POR风险增加有显著的关联,特别是在高加索人群中.
这些发现有助于了解POR的遗传基础,并可能为个性化试管婴儿策略提供信息.

关键词:

在FSHR的FSHR.在这个过程中,IVF IVF.进行元分析分析.在 PORT PORT 的位置上,我们可以看到多态性多态性多态性印度6165卢比印度6166卢比

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