为什么DR-TB患者没有完成治疗? 来自巴基斯坦的一项定性研究的结果
Muhammad Abubakar1,2, Matti Ullah3, Muhammad Aamir Shaheen4
1Faculty of Pharmacy, Hamdard University - Islamabad Campus, Islamabad, Pakistan mabubakar.pharmacist@gmail.com.
BMJ open respiratory research
|February 27, 2024
概括
在巴基斯坦,由于患者,药物,社会经济和服务因素,耐药结核病 (DR-TB) 治疗中的随访损失 (LTFU) 高. 解决这些障碍可以改善治疗结果,降低LTFU率.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 结核病研究 结核病研究
背景情况:
- 高的随访损失率 (LTFU) 显著阻碍了耐药结核病 (DR-TB) 患者的成功治疗结果.
- 巴基斯坦缺乏质量研究,详细介绍LTFU患者的感知,挑战和停止治疗DR-TB的原因.
研究的目的:
- 质量地探索LTFU患者对DR-TB治疗的看法.
- 确定LTFU患者所面临的具体问题,以及他们在巴基斯坦不遵守DR-TB治疗的根本原因.
主要方法:
- 一项定性研究涉及半结构化,深入的面对面采访,对39名被诊断患有DR-TB的LTFU患者进行了面对面采访.
- 采访以乌尔都语进行,分两个阶段进行:2020年12月至2021年2月 (广泛耐药结核病) 和2021年7月至2021年9月 (多药耐药结核病).
主要成果:
- 归纳性主题分析揭示了四个关键主题,这些主题有助于LTFU:
- 与患者相关的因素:缺乏意识,治疗疲劳,对疗效的信念较低,以及对不可治愈性的看法.
- 与药物相关的因素:注射剂,药物负担,长时间和不良事件.
- 社会经济因素:性别歧视,贫困,缺乏家庭支持,社会孤立和失业.
- 与服务提供商相关的因素:遥远的中心,不合格的员工,不充分的咨询和医疗保健专业人员的不良态度.
结论:
- 患者的看法,社会经济状况,药物问题和服务提供商因素是完成DR-TB治疗的重大障碍.
- 降低LTFU的策略包括提高患者意识,同行支持,快速诊断,分散护理和全口服疗法.
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