在患有1型糖尿病的儿童中快速发展胰岛素缺乏症的预测生物标志物
Per Lundkvist1, Annika Grönberg2, Per-Ola Carlsson3,4
1Department of Medical Sciences, Uppsala University, Uppsala, Sweden per.lundkvist@medsci.uu.se.
BMJ open diabetes research & care
|February 27, 2024
概括
生物标志物不能可靠地预测儿童1型糖尿病的进展. 虽然一些像CAR这样的标记物在快速进展者中随着时间的推移显示出变化,但总的来说,预测疾病速度仍然具有挑战性.
科学领域:
- 内分泌学和新陈代谢学
- 免疫学 免疫学 免疫学
- 儿科 儿科 儿科
背景情况:
- 1型糖尿病的进展到胰岛素缺乏有很大的差异.
- 预测疾病进展对于儿童1型糖尿病的干预试验至关重要.
- 需要确定快速与缓慢进展的生物标志物.
研究的目的:
- 确定预测新发型1型糖尿病儿童疾病进展的快速或缓慢的生物标志物.
- 为了比较快速和缓慢进展者和健康对照之间的生物标志物概况.
主要方法:
- 在46名患有1型糖尿病的儿童中进行了回顾性纵向队列研究.
- 根据C-水平将儿童分为快速 (<30个月) 和缓慢进展者.
- 在基线和随访时使用近距离延伸试验 (PEA) 评估了多种生物标志物,包括健康的对照组 (N=45).
主要成果:
- 快速进展者在基线时具有较低的C-和较高的自身抗体.
- 在快速治疗组中,三个基线生物标志物 (碳酸无水酶9,皮质类固醇11-β-脱酶异酶1,瘤亡因子受体超级家族成员21) 的水平较高.
- 一个coxsackievirus B-adenovirus受体 (CAR) 随着时间的推移增加,特别是在快速进展者中;81种蛋白质在1型糖尿病和对照者之间存在差异,但PCA无法区分进展组.
结论:
- 对多种生物标志物的近距离扩展试验 (PEA) 分析无法区分儿童1型糖尿病进展率.
- 考萨基病毒B-腺病毒受体 (CAR) 显示了快速进展的时间依赖的显著增加.
- 特定的生物标志物仍然可以提供关于C-下降和1型糖尿病病原体的见解,尽管预测进展速度的局限性.
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