根据禁食血糖轨迹的癌症风险:基于人口的队列研究
Thi Minh Thu Khong1, Thi Tra Bui2, Hee-Yeon Kang2
1Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang 10408, Republic of Korea.
BMJ open diabetes research & care
|February 27, 2024
概括
随着时间的推移,不受控制的高空腹血糖 (FBG) 会显著增加癌症风险. 这项研究确定了与各种癌症发病率较高相关的特定FBG轨迹,包括肝癌,胃肠癌和胃癌.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 糖尿病是一种已知的癌症发展风险因素.
- 随着时间的推移,空腹血糖 (FBG) 水平的动态变化及其与癌症风险的关联需要进一步调查.
- 这项研究侧重于韩国人口,以探索FBG轨迹与癌症发病率之间的联系.
研究的目的:
- 分析不同禁食血糖 (FBG) 轨迹与患癌症的风险之间的关系.
- 为了识别特定的癌症类型,与随着时间的推移FBG水平的独特模式相关.
- 提供关于葡萄糖失调对癌症风险的长期影响的见解.
主要方法:
- 利用了来自国家健康保险服务-国家健康查队列 (2002-2015) 的256,271名韩国参与者 (40-79岁) 的数据.
- 采用基于组的轨迹建模来定义FBG轨迹 (低稳定,高稳定,高稳定,高稳定).
- 应用了Cox的比例危险模型来评估与FBG轨迹相关的癌症发病率风险,并对共变量进行调整.
主要成果:
- 确定了四种不同的FBG轨迹:低稳定,高稳定,高稳定和高稳定.
- 高稳定的FBG组显示多发性骨髓瘤,肝脏和胃肠道癌症的风险增加.
- 升高的稳定和升高的FBG轨迹与整体癌症,胃癌,口腔癌,肝癌和胰腺癌的风险增加有关.
结论:
- 长期保持高的空腹血糖水平与各种癌症的风险增加有关.
- 识别特定的FBG轨迹可以帮助分层个体的癌症风险.
- 这项研究强调了长期血糖控制在癌症预防策略中的重要性.
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