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与益生菌使用相关的Clostridium butyricum细菌病,日本
Emerging infectious diseases
|February 27, 2024
概括
像MIYA-BM这样的Clostridium butyricum益生菌可以在住院患者中引起细菌病. 遗传分析证实这些感染源于益生菌菌株,突出了与它们使用相关的风险.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 基因组学就是基因组学.
背景情况:
- Clostridium butyricum 是一个在亚洲广泛使用的益生菌.
- 来自C.butyricum的细菌病是罕见但严重的不良事件.
- 目前尚不清楚C. butyricum细菌病的患病率和遗传基础.
研究的目的:
- 为了确定C. butyricum bacteremia的流行率.
- 描述这些感染的临床和遗传特征.
- 为了确定C. butyricum bacteremia的来源.
主要方法:
- 从2011年9月到2023年2月的住院病人的回顾性分析.
- 从阳性血液培养物中分离的细菌的全基因组测序.
- 检查患者病历以获取临床信息.
主要成果:
- 在6576名血培养阳性患者中发现了5例 (0.08%) 的C. butyricum细菌性病例.
- 四名患者服用了MIYA-BM,一名患者使用了另一种C. butyricum益生菌.
- 全基因组测序证实所有细菌菌菌株都是益生菌衍生物,通常与免疫功能低下的患者有关.
结论:
- 益生菌C.butyricum可以导致细菌病,特别是在免疫系统受损的住院患者中.
- 合理的益生菌处方是必要的,以减轻风险.
- 基因测序对于确定C. butyricum bacteremia的起源至关重要.
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