一个神经解剖学和病理生理学框架,用于治疗创伤后应激障碍的新药学方法
Michael A Norred1,2, Zachary D Zuschlag1,2, Mark B Hamner3,4
1Mental Health and Behavioral Sciences Service, James A. Haley Veterans Hospital, Tampa, FL, USA.
Drugs
|February 27, 2024
概括
除了SSRI之外,创伤后应激障碍 (PTSD) 的新疗法正在出现. 本综述探讨了针对PTSD的非血清药物和迷幻疗法.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 创伤后应激障碍 (PTSD) 带来了显著的症状和社会经济负担.
- 目前FDA批准的PTSD治疗方法,主要是SSRI,由于复杂的病理生理学,具有局限性.
- 创伤后应激障碍的复杂性涉及神经递质,神经电路和神经解剖路径.
研究的目的:
- 审查创新和新兴的PTSD治疗方法.
- 检查用于PTSD管理的非血清激素途径和迷幻干预措施.
- 将新的治疗剂整合到创伤相关疾病的病理生理学框架中.
主要方法:
- 对正在开发的药物的审查和对PTSD的临床测试.
- 研究已确定的药物和化合物用于PTSD的实用性.
- 对创伤后应激障碍的新兴迷幻干预措施的分析.
主要成果:
- 多种新型非血清激素药物处于不同发展阶段 (例如,BI 1358894,BNC-210).
- 已经确立的化合物如布雷克斯皮普拉,大麻和加纳克索隆正在研究PTSD.
- 迷幻疗法,包括胺,MDMA和 псилоцибин,在PTSD治疗方面表现有前途.
结论:
- 除了血清能系统之外的替代途径为PTSD药物开发提供了有希望的目标.
- 多种新的药物和迷幻干预措施可以改善PTSD管理.
- 将这些新兴治疗方法与病理生理学理解相结合,对于推进创伤障碍护理至关重要.
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