梦与睡眠和精神病特征有共同的遗传风险因素
Hanna M Ollila1,2,3,4, Nasa Sinnott-Armstrong5, Katri Kantojärvi6,7
1Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Translational psychiatry
|February 27, 2024
概括
频繁的梦与与焦虑,抑郁和神经病的共同遗传因素有关. 失眠也可能因果关系增加经历梦的风险.
科学领域:
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
- 睡眠医学 睡眠医学
背景情况:
- 频繁的梦与情绪调节问题和精神疾病如失眠,抑郁和焦虑有关.
- 梦和它们的并发症之间的遗传基础和因果关系仍然不太清楚.
研究的目的:
- 为了调查梦的遗传风险因素.
- 估计梦和相关并发症之间的遗传相关性和因果关系.
主要方法:
- 一项全基因组关联研究 (GWAS) 对45,255名个人进行,使用关于梦频率和基因型化数据的问卷数据.
- 进行了基因相关性和门德尔随机化分析,以评估与精神病特征和失眠的关系.
主要成果:
- 在GWAS没有确定特定的风险变体,但可怕梦的遗传率估计为5%.
- 在梦和焦虑 (rg=0.671),抑郁 (rg=0.562),创伤后应激障碍 (rg=0.4083) 和神经症 (rg=0.667) 之间发现了显著的遗传相关性.
- 门德尔的随机化表明,失眠与梦之间存在因果关系 (β=0.027).
结论:
- 梦有着共同的遗传背景和几个精神病特征.
- 失眠可能是一个因果因素,增加了经常经历梦的可能性.
- 提高对梦的认识和系统的数据收集至关重要,特别是在临床和大型队列研究中.
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