一个关于环境抗生素耐药性基因的数据库
Wenjuan Xu1,2, Zhizhen Pan1, Yangyu Wu1
1Xiamen Key Laboratory of Indoor Air and Health, Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, China.
Scientific data
|February 27, 2024
概括
这项研究创建了中国抗生素耐药性基因 (ARG) 的综合数据库,详细介绍了它们在各种环境中的丰富性和分布. 本资源有助于了解抗菌素耐药性 (AMR) 的传播和评估健康风险.
科学领域:
- 环境科学环境科学
- 微生物学 微生物学
- 公共卫生 公共卫生
背景情况:
- 抗菌素耐药性 (AMR) 是一个全球性的健康危机.
- 环境抗生素耐药性基因 (ARG) 通过微生物之间转移,对抗菌素耐药性有显著的贡献.
- 对于ARGs的时空分布,丰度和健康风险,存在有限的数据库.
研究的目的:
- 编制和呈现一个全面的ARG发生和丰富的数据库在中国.
- 为研究ARG动态和评估AMR健康风险提供数据.
- 建立一个环境抗菌药物耐药性研究的基础资源.
主要方法:
- 编制了来自中国18个省份653个地点的1,403个样本的ARG发生数据.
- 使用高通量定量PCR平台进行数据生成.
- 从2013年到2020年收集了290个ARG和30个移动遗传元素 (MGE) 的数据.
主要成果:
- 开发了一个数据库,包含291,870个ARG记录和8,057个MGE记录.
- 数据涵盖了五种息地类型和ARG,对15种抗生素类型产生了耐药性.
- ARG代表了五个主要的抵抗机制和四个风险等级.
结论:
- 创建的数据库为ARG分布和丰富性提供了有价值的见解.
- 它是了解抗菌药物耐药性动态的关键工具.
- 该数据库支持与抗菌素耐药性相关的健康风险评估.
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