德黑兰纵向基于家庭的心脏代谢队列研究对失脂症传播模式进行了新的研究
Mahdi Akbarzadeh1, Parisa Riahi1, Amir Hossein Saeidian2
1Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Scientific reports
|February 27, 2024
概括
脱脂症的家族传播很强,遗传率为42%. 患有脂质障碍的父母显著增加了风险,特别是在同性兄弟姐妹之间.
科学领域:
- 心血管遗传学 心血管遗传学
- 代谢障碍 代谢障碍 代谢障碍
- 人口健康 人口健康
背景情况:
- 脱脂症是全球心血管疾病的主要遗传风险因素.
- 了解家族传播模式对于有针对性的干预至关重要.
研究的目的:
- 为了调查失脂症的家族传播模式.
- 在一个大型的伊朗队列中估计失脂症及其脂质成分的遗传性.
主要方法:
- 纵向基于家庭的队列研究 (德黑兰心脏代谢遗传研究 - TCGS).
- 包括18,729名超过5个3年后续期的个人.
- 使用混合效应模型分析血清脂质度 (总胆固醇,甘油三,HDL-C,LDL-C) 和遗传性.
主要成果:
- 脱脂症的周期性流行率和遗传率分别为65.7%和42%.
- 患有至少一个失脂症父母的个体患有失脂症的几率增加了6.94倍.
- 同性兄弟姐妹之间观察到最高的类内相关性 (25.5%);脂质度的遗传性从33.64%到60.95%.
结论:
- 在德黑兰人口中存在严重的血脂不良的家族传播.
- 同性兄弟姐妹显示出最显著的家族聚合的失脂症.
- 在这个人群中,失脂症的遗传性明显高于全球平均水平.
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