在两种老年动物模型中,稳定SARS-CoV-2尖端糖蛋白的免疫疗效
Carla Usai1,2, Erola Ainsua-Enrich3, Victor Urrea Gales3
1Unitat Mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.
NPJ vaccines
|February 27, 2024
概括
这项研究调查了老年动物中SARS-CoV-2 (COVID-19) 疫苗的疗效,发现与年轻人相比,保护性降低. 在老年人群中测试疫苗对于有效的临床前评估至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 老年学是指老年学的学科.
背景情况:
- 衰老与疫苗有效性降低和严重COVID-19风险增加有关.
- 之前的研究表明,S-29 SARS-CoV-2 疫苗在年幼动物中具有很高的疗效.
- 临床前评估往往缺乏老年人群的代表性.
研究的目的:
- 确定衰老对S-29 SARS-CoV-2疫苗疗效的影响.
- 为了评估疫苗诱导的防治SARS-CoV-2的挑战在老年金色的叙利亚仓鼠 (GSH) 和K18-hACE2小鼠.
- 突出在疫苗临床前研究中包括老年动物的必要性.
主要方法:
- 对老年GSH和K18-hACE2小鼠进行了AddaVaxTM辅助剂中的S-29蛋白两次免疫接种.
- 动物在免疫接种后的不同时间点受到SARS-CoV-2的挑战.
- 挑战后对临床症状,体重,病毒载量和组织病变进行了监测.
主要成果:
- 免疫引发了血清转化和中和抗体,但只提供了对减肥的部分保护.
- 在接种疫苗的动物中观察到病毒RNA的显著减少和病毒蛋白质清除的加快.
- 虽然小鼠的生存率有所改善,但与年轻动物相比,S-29疫苗在老年人群中的有效性降低了.
结论:
- 在老年动物中,S-29 SARS-CoV-2 疫苗的疗效降低.
- 临床前疫苗评估必须包括老年病例模型,以确保广泛适用.
- 与年龄相关的免疫变化影响了针对SARS-CoV-2的疫苗性能.
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