评估茶饮与牙损伤和牙周炎风险之间的关联:一项两样本的孟德尔随机化研究
Bilun Jin1,2,3, Heng Chen4, Peiqi Liu1,2,3
1Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, China.
Scientific reports
|February 27, 2024
概括
更高的茶饮可能与更高的牙周炎风险有关,但不是牙损伤. 这项门德尔随机化研究表明了潜在的因果关系,尽管社会经济因素可能会影响这种关联. 需要进一步的研究.
科学领域:
- 口腔卫生流行病学 口腔卫生流行病学
- 营养基因组学 营养基因组学
- 遗传流行病学遗传流行病学
背景情况:
- 茶饮与口腔健康结果 (如牙损伤和牙周炎) 之间的关系仍在争论中.
- 全基因组关联研究 (GWAS) 为调查生活方式与疾病的关联提供了有价值的遗传数据.
研究的目的:
- 调查基因预测的茶饮量与牙损伤和牙周炎风险之间的潜在因果关系.
- 探索吸烟,BMI和社会经济地位等混因素对这种关系的影响.
主要方法:
- 利用孟德尔的随机化 (MR) 分析,用38个单核酸多态 (SNP) 与茶摄入量作为仪表变量 (IVs) 相关.
- 采用多变量门德尔随机化 (MVMR) 来调整潜在的混因素.
- 通过异质性和质性测试评估了MR研究的有效性.
主要成果:
- 较高的茶饮量与较少的天然牙和牙周炎风险增加有关.
- 红茶摄入量和牙周炎之间的因果关系在邦费罗尼校正后仍然显著,但在调整社会经济因素时失去了意义.
- 在茶饮量和牙损伤风险之间没有发现显著的关联.
结论:
- 基因预测较高的茶饮可能与牙周炎的风险增加有关,可能由社会经济因素介导.
- 茶的摄入似乎对牙腐烂的风险没有因果关系.
- 这些发现有助于理解饮食生活方式在预防口腔疾病中的作用.
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