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阻塞性多变性心肌病症中的心肌桥:心肌纤维化的一个危险因素

Changpeng Song¹, Shengwei Wang², Xinli Guo¹

¹Department of Special Medical Treatment Center in Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing, 100037, People's Republic of China.

|February 27, 2024

概括

肌心桥架 (MB) 与严重的缩压缩与高性心肌病 (HCM) 患者心肌纤维化增加有关. 综合管理严重的MB可能会改善HCM的预后.

科学领域:

心脏病学心脏病学
心血管成像 - 心血管成像
心脏病理学心脏病理学

背景情况:

肌心桥架 (MB) 经常在患有多变性心肌病 (HCM) 的患者中观察到.
在HCM的背景下,关于MB对心肌纤维化的影响的数据有限.
这项研究调查了在阻塞性HCM中MB和心肌纤维化之间的关联.

研究的目的:

评估心肌桥架和心肌纤维化在患有阻塞性多变性心肌病的患者之间的关系.
为了确定心肌纤维化程度是否与心肌纤维化程度相关,在MB中压缩系统的程度.
评估MB在阻塞性HCM的预后影响.

主要方法:

回顾性队列研究包括492名患有阻塞性HCM的患者,他们接受了隔膜肌切除术.
术前心磁共振成像 (CMR) 用于评估心肌纤维化 (晚期加多增强 - LGE) 和缩压缩.
数据从2011年到2018年在一个大批量的中华人民共和国中心收集.

主要成果:

76名患者 (15.5%) 患有MB,主要在左前下降动脉.
在缩压缩的程度和LGE的全球范围 (r=0.33,p=0.003) 之间发现了显著的相关性.
与轻度至中度的MB相比,严重的MB (压缩比≥80%) 与特定心肌段中的LGE分数显著增加有关.

结论:

在阻塞性HCM中,严重的心肌桥梁与显著的缩压缩独立地与更高程度的心肌纤维化有关.
在患有MB的患者中,诸如肌肉切除或旁路移植之类的手术干预可能会导致与没有MB的患者相似的生存率.
识别和管理患有严重MB的患者对于可能改善HCM的结果至关重要.

关键词:

纤维化纤维化纤维化过度缩性心肌病变性是一种心脏病变.心肌架构桥梁是指心肌架构桥梁.幸存的生存方式

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