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上部和中部直肠癌的关节保护手术后的长期肠功能结果:单中心纵向研究
Ahmad Sakr1,2, Seung Yoon Yang2, Min Soo Cho2
1Colorectal Surgery Unit, Department of General Surgery, Mansoura Faculty of Medicine, Mansoura University Hospitals, Mansoura, Egypt.
Annals of coloproctology
|February 28, 2024
概括
对直肠癌的新辅助化疗放射治疗可以导致显著的肠功能障碍和便失禁,特别是在低瘤的情况下. 这种功能障碍在手术后至少持续两年,影响生活质量.
科学领域:
- 结肠直肠外科手术是什么意思
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
背景情况:
- 肠道功能障碍是直肠癌治疗后常见的,限制生活质量的并发症.
- 新辅助化学放射治疗和关节保护手术的进步并没有消除这个问题.
研究的目的:
- 为了研究直肠癌前下切除后肠功能的纵向变化.
- 评估新辅助化学放射治疗对肠道功能的特定影响.
主要方法:
- 评估了171名患上/中直肠癌的患者,这些患者接受了低前切除.
- 每6个月使用经过验证的仪器 (MSKCC BFI,韦克斯纳分数) 纵向评估肠道功能.
- 在分析中包括了至少两次随访的患者.
主要成果:
- 新辅助性化疗或放射性疗法给了100名患者.
- 在新辅助化疗和放射治疗组中,在24个月内观察到显著的肠功能障碍,包括急性,污垢和便失禁.
- 低瘤水平和新辅助化学放射治疗独立地与延迟肠道功能障碍有关.
结论:
- 新辅助性化疗与低瘤水平相结合,显著预测低前切除后的延迟肠功能障碍.
- 这些发现凸显了需要仔细选择患者和彻底讨论潜在的长期功能结果的必要性.
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