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接种BCG疫苗和多发性硬化症风险:挪威队列研究

Ola Nakken¹, Jan Harald Aarseth², Stig Wergeland³

¹Department of Neurology, Akershus University Hospital, Lørenskog, Norway.

Multiple sclerosis (Houndmills, Basingstoke, England)

|February 28, 2024

概括

在成年早期接种Bacillus Calmette-Guérin (BCG) 疫苗并没有降低患多发性硬化症 (MS) 的风险. 这项大型研究发现,BCG疫苗接种,结核病感染和随后的多发性硬化症风险之间没有联系.

科学领域:

免疫学免疫学免疫学
神经学神经学
流行病学流行病学

背景情况:

众所周知,Bacillus Calmette-Guérin (BCG) 疫苗可以调节免疫反应.
以前的研究表明,BCG可以预防自身免疫性疾病,如实验性自身免疫性脑膜炎,并可能影响多发性硬化症 (MS) 的活性.

研究的目的:

调查在成年早期接受BCG疫苗接种是否与患MS的风险降低有关.

主要方法:

分析了1963年至1975年期间接种结核疫苗的791,369名挪威人的队列.
多发性硬化症的诊断是通过国家登记处确定的.
使用后勤回归模型来评估BCG疫苗接种状态与MS风险之间的关联.

主要成果:

在成年早期BCG疫苗接种与患MS的风险之间没有发现显著的关联.
与没有结核病感染的未接种疫苗的个人相比,BCG接种疫苗的个人中MS的几率比率为1.00 (95% CI:0.80-1.25) .
潜在的结核病感染似乎没有影响BCG和MS风险之间的关系.

结论:

年轻人接受BCG疫苗接种似乎不会降低患多发性硬化症的风险.
在年轻的成年期内潜伏结核病感染也没有被发现与MS风险有关.

关键词:

巴西勒斯镇静格林.多发性硬化症是多发性硬化症.队列研究是指队列研究.流行病学流行病学有关风险因素的风险因素.疫苗,疫苗,疫苗的使用情况.

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