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氧化应激和慢性面部疼痛与潜在的可药物点之间的关联:来自孟德尔随机化研究的证据

Shao-Hui Zhang¹, Yao Feng², Meng-Mei Zhong²

¹Department of Stomatology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, China.

Journal of oral rehabilitation

|February 28, 2024

概括

这项研究表明,较低的尿酸 (UA) 水平与肌关节疼痛有关,而较高的谷氨转移酶 (GST) 水平与牙脉疼痛有关. 这些发现表明了慢性口腔面部疼痛的潜在新疗法.

科学领域:

遗传学是一个遗传学.
生物标志物生物标志物
疼痛研究疼痛研究

背景情况:

氧化应激在慢性口腔面部疼痛 (COFP) 中发挥着作用,但有效的减少策略尚不清楚.
确定与COFP相关的特定氧化应激生物标志物对于开发有针对性的干预措施至关重要.

研究的目的:

使用孟德尔随机化 (MR) 调查11种氧化应激生物标志物和四种COFP之间的因果关系.
通过探索与氧化应激相关的可用药物标来确定COFP的潜在治疗标和生物标志物.

主要方法:

利用逆方差加权门德尔随机化 (IVW-MR) 来评估氧化应激生物标志物的对COFP的影响.
在基于SNP的功能丰富分析中使用功能映射和注释 (FUMA).
应用IVW-MR通过结合基因变异的效果估计来确定潜在的可用药物点.

主要成果:

发现尿酸 (UA) 和肌肌带疼痛 (OR 0.998) 和谷氨转移酶 (GST) 和牙膜膜疼痛 (OR 1.002) 之间存在显著的关联.
功能性分析显示,UA和肌肌带疼痛基因参与和 uracil 的新陈代谢.
GST和dentoalveolar疼痛基因在谷氨代谢中得到丰富,其中SLC2A9和GSTA2分别涉及肌关节和dentoalveolar疼痛.

结论:

基因预测的肌肌关节疼痛与UA减少有关,而牙痛与GST增加有关.
SLC2A9和GSTA2抑制剂代表了慢性口腔面部疼痛的新潜在疗法和生物标志物.
需要进一步的临床试验和研究来验证这些发现并探索潜在的机制.

关键词:

慢性口腔面部疼痛 2 慢性口腔面部疼痛门德尔的随机化 5 门德尔的随机化分子药物 4 分子药物 4 口腔疾病 3 口腔疾病 3 氧化应激 1 氧化应激 1

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