在全原造血细胞移植中的年龄障碍:升起银幕
Pashna N Munshi1, Shannon R McCurdy1
1Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
American journal of hematology
|February 28, 2024
概括
全基性造血细胞移植 (HCT) 现在是老年人的一种可行的选择. 本综述审查了当前针对老年人的HCT实践,并建议改进患者评估和护理指南.
科学领域:
- 血液学 血液学 血液学
- 移植医学 移植医学
- 老年医学 老年医学
背景情况:
- 全基性造血细胞移植 (HCT) 越来越多地用于老年成人群体.
- 非密集治疗和移植与宿主疾病预防方面的进步扩大了HCT的资格.
- 人口变化需要更新患者管理方法.
研究的目的:
- 审查老年人中HCT的历史背景和当前状态.
- 提出一个结构化的评估和干预框架,以优化HCT候选人.
- 为应对老年HCT接受者现有的临床指南的局限性.
主要方法:
- 对老年人高血压试验的文献综述.
- 分析老年人医疗保健的当前趋势和挑战.
- 拟议评估和干预流程的开发.
主要成果:
- 在老年患者群体中,HCT越来越可行和成功.
- 现有的风险分层和移植前优化协议需要针对老年人进行调整.
- 一种结构化的方法可以改善老年HCT接受者的结果.
结论:
- 造血细胞移植是不断扩大的老年人群的可行治疗选择.
- 目前的临床指导方针需要改进,以充分满足老年HCT候选人的独特需求.
- 一项拟议的评估和干预策略旨在弥补现有的医疗护理差距.
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