接种COVID-19疫苗:需要更多的注射剂还是我们现在免疫?
Michelle L Giles1,2, Katie L Flanagan3,4,5,6
1Department of Infectious Diseases, University of Melbourne, Melbourne, Victoria, Australia.
Internal medicine journal
|February 28, 2024
概括
针对COVID-19疫苗接种和感染的混合免疫力提供了卓越的保护. 澳大利亚 澳大利亚 澳大利亚
科学领域:
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
- 疫苗学 疫苗学 疫苗学
背景情况:
- COVID-19疫苗对传染和感染提供有限的保护,但对严重疾病和死亡提供强有力的保护.
- 由于接种疫苗和自然感染而产生的混合免疫力,与单独的免疫力相比,提供了更好的保护.
- 澳大利亚拥有高度接种疫苗的人口,具有广泛的混合免疫力,主要来自原始菌株疫苗和Omicron感染.
研究的目的:
- 评估从2024年起对进一步的COVID-19疫苗剂量的必要性和目标人群.
- 考虑SARS-CoV-2变种发展的影响,特别是从武汉菌株转向Omicron的转变.
- 评估从双价疫苗过渡到新的Omicron XBB菌株专用疫苗的情况.
主要方法:
- 审查有关COVID-19疫苗有效性,自然感染和混合免疫力的现有文献.
- 对澳大利亚疫情情情景观的分析,涉及疫苗接种率和感染流行率.
- 检查SARS-CoV-2菌株的演变和疫苗的开发,包括双价和Omicron XBB配方.
主要成果:
- 澳大利亚目前的杂交免疫力在很大程度上是基于较旧的疫苗菌株和Omicron感染.
- 随着SARS-CoV-2的演变,Omicron血统变种在全球范围内取代了原始的武汉菌株.
- 新的XBB专用疫苗正在取代旧配方,需要重新评估疫苗接种策略.
结论:
- 持续需要COVID-19疫苗接种,包括潜在的未来剂量,需要仔细考虑.
- 最佳的疫苗成分 (例如,基于武汉的,双价或XBB特异性) 和辅助剂的目标人群需要持续评估.
- 未来的疫苗接种策略必须适应循环的SARS-CoV-2变种,以保持人口的保护.
更多相关视频
09:37Detection of Polyfunctional T Cells in Children Vaccinated with Japanese Encephalitis Vaccine via the Flow Cytometry Technique
Published on: September 23, 2022
1.9K
09:03Rapid In Vivo Assessment of Adjuvant's Cytotoxic T Lymphocytes Generation Capabilities for Vaccine Development
Published on: June 19, 2018
8.7K
相关概念视频
Vaccinations
44.5K
Overview
44.5K
Immunological Memory
611
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
611
Active versus Passive Immunity
642
Immunity, along with the ability to limit pathogen growth to prevent significant body tissue damage, can be gained either by (1) actively developing an immune response within the individual after exposure to a pathogen or after getting vaccinated or (2) passively transferring immune components from an immune individual to one who is nonimmune. Both these forms of immunity can be found naturally and in medical practices.
Active Immunity
Active immunity refers to the resistance one develops...
Active Immunity
Active immunity refers to the resistance one develops...
642
Cross-reactivity
31.1K
Overview
31.1K
Immunodeficiency Diseases
937
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
937
Immune Response Against Viral Pathogens
781
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
781
