来自美国牛群的两种牛肝炎病毒基因组序列
Aspen M Workman1, Gregory P Harhay1, John T Groves2
1U.S. Meat Animal Research Center, U.S. Department of Agriculture, Agricultural Research Service, Clay Center, NE, USA.
概括
牛肝炎病毒 (BoHV) 与人类肝炎C病毒 (HCV) 有关,最近在美国牛群中被测序. 这项研究揭示了美国牛肉群中的基因多样性和不同BoHV菌株的共同循环.
科学领域:
- 兽医病毒学 兽医病毒学
- 比较病毒学比较病毒学
- 分子流行病学分子流行病学
背景情况:
- 牛肝炎病毒 (BoHV) 是一种新出现的病毒,与人类型肝炎病毒 (HCV) 密切相关.
- 牛的BoHV感染可以导致牛的急性和慢性肝病.
- 以前的BoHV监测一直是有限的,特别是在美国,可能低估了它的遗传多样性.
研究的目的:
- 在美国牛群中描述牛肝炎病毒 (BoHV) 的遗传多样性.
- 报告美国牛群中BoHV分离物的第一个基因组序列.
- 分析美国BoHV菌株与全球隔离品的遗传学关系.
主要方法:
- 从密苏里州收集的牛肉牛血清样本中测序了两个几乎完整的BoHV基因组.
- 遗传学分析和序列同质性比较.
主要成果:
- 从美国牛群中测序了两个不同的BoHV基因组.
- 一个分离物 (MARC/2019/60) 与中国的基因型1,亚型E菌株具有很高的同质性.
- 第二个隔离物 (MARC/2019/50) 代表了BoHV基因型2中的新型亚型,标志着全球第二个完整的BoHV2基因组.
结论:
- 这项研究提供了美国牛群中BoHV的第一个基因组特征.
- 这些发现表明,在美国的牛群中,基因分歧的BoHV菌株的共同循环.
- 这项工作扩大了对全球BoHV遗传多样性的理解,并强调了持续监测的必要性.
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