在给予GEN-001 (Lactococcus lactis) 后,内源代谢物和肠道微生物分布的变化进行分析
Min-Gul Kim1,2,3, Suin Kim4, Ji-Young Jeon1
1Center for Clinical Pharmacology, Jeonbuk National University Hospital, Jeonju 54907, Korea.
概括
一剂 Lactococcus lactis GEN-001 在健康的男性中平衡了肠道微生物群,增加了有益的细菌和免疫代谢物. 这种益生菌干预显示了肠道健康调节的潜力.
科学领域:
- 微生物学 微生物学
- 代谢学 代谢学 代谢学
- 免疫学 免疫学 免疫学
背景情况:
- 肠道微生物群在宿主健康中起着至关重要的作用.
- 益生菌,如Lactococcus lactis GEN-001,正在研究它们对调节肠道微生物组成和功能的潜力.
研究的目的:
- 为了确定代谢生物标志物和肠道微生物群的变化后的Lactococcus lactis GEN-001.1.的管理.
- 在健康的韩国男性中评估单剂量GEN-001的安全性和效果.
主要方法:
- 一个平行的,随机的,第一阶段的开放标签试验,涉及20名健康男性.
- 施用不同剂量的乳球菌GEN-001 (1-9个囊).
- 分析便样本以检测非向的代谢学和代谢基因组学,以及血液样本以检测免疫性.
主要成果:
- 药物注射后氨酸,氨酸,胆酸,脱氧胆酸和氨酸水平显著增加.
- 降低了Parabacteroides和Alistipes的相对丰度,增加了Lactobacillus和Lactococcus的丰度.
- 在乳酸菌和托芬水平之间观察到负相关性.
结论:
- 在健康的志愿者中,单次服用Lactococcus lactis GEN-001有效地将肠道微生物群转向更平衡的状态.
- 观察到有益细菌和免疫原代谢物的增加表明对肠道健康有积极的影响.
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