当心脏抑制大脑时:心脏相调节短间隔的皮质内抑制
Mario Paci1, Pasquale Cardellicchio2,3,4, Paolo Di Luzio5
1Department of Neuroscience, Imaging and Clinical Science, University G. D'Annunzio, Chieti-Pescara, Chieti, Italy.
iScience
|February 28, 2024
概括
心血管活动会影响大脑. 研究人员发现,心脏相对运动皮质的短内皮层抑制 (SICI) 有影响,特别是缩期间的GABAA-ergic神经传递.
科学领域:
- 神经科学是一个神经科学.
- 心血管生理学心血管生理学
- 发动机控制器的控制器
背景情况:
- 由巴罗受体输入驱动的相性心血管活动对中枢神经系统和行为产生抑制作用.
- 了解心血管节律和神经刺激性之间的相互作用对于破译运动控制机制至关重要.
研究的目的:
- 为了研究心脏阶段 (心缩和心腹缩) 对皮质脊髓刺激 (CSE) 和皮质内运动抑制的影响.
- 为了区分GABAA介导 (短间隔内皮层抑制,SICI) 和GABAB介导 (长间隔内皮层抑制,LICI) 在初级运动皮层内的神经传递的影响 (M1).
主要方法:
- 在休息状态下,在左主运动皮层 (M1) 上利用了跨膜磁刺激 (TMS).
- 测量了不同心脏阶段 (静心和腹心) 的皮质脊髓刺激性 (CSE),短内皮质抑制 (SICI) 和长内皮质抑制 (LICI).
主要成果:
- 观察到心脏阶段对短内皮层抑制 (SICI) 有显著影响.
- 具体来说,SICI在心缩期间明显强于心缩期间.
- 没有发现心脏阶段对长内皮层抑制 (LICI) 的显著影响.
结论:
- 心脏周期对主要运动皮层 (M1) 中的GABAA-ergic介导的运动抑制产生显著的调节作用.
- 这表明心血管活动和皮质内抑制过程之间的动态相互作用,可能与运动控制和关门机制有关.
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