埃塞俄比亚乳腺癌的决定因素:系统审查和元分析
Lencho Kajela Solbana1, Eshetu Ejeta Chaka2
1College of Health Science, Assosa University, PO Box 018, Assosa, Ethiopia.
Ecancermedicalscience
|February 28, 2024
概括
初潮的早期年龄,绝经后和家族癌症史是埃塞俄比亚妇女乳腺癌 (BC) 的关键决定因素. 相反,一直母乳养与BC的风险降低有关.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 乳腺癌 (BC) 是全球女性的主要癌症,约占总癌症负担的25%.
- 埃塞俄比亚面临着与BC的重大挑战,需要对其在人口中的特定决定因素进行研究.
研究的目的:
- 确定与埃塞俄比亚妇女乳腺癌 (BC) 相关的重大风险因素和保护因素.
- 为旨在减少埃塞俄比亚BC发病率和死亡率的公共卫生干预提供基于证据的建议.
主要方法:
- 对埃塞俄比亚进行的初级研究进行了系统审查和元分析.
- 通过多个数据库 (PubMed,Cochrane图书馆,Hinari,谷歌,谷歌学者) 搜索研究,截至2023年6月2日.
- 来自五项涉及1819名参与者的研究数据被分析,使用随机效应模型来估计聚合概率比率 (AOR) 和95%置信区间 (CI).
主要成果:
- 确定的BC的主要决定因素包括初潮的早期年龄 (<12岁) (AOR=3.36,95% CI:1.68-5.04) 和绝经后 (AOR=2.37,95% CI:1.67-3.06).
- 癌症家族史也是一个显著的风险因素 (AOR=2.39,95% CI:1.29-3.44).
- 长期母乳养被发现是一种保护因素,显著降低了BC风险 (AOR=0.28,95%CI:0.15-0.42).
结论:
- 该研究强调初潮时的年龄,更年期状态,母乳养史和家族史是埃塞俄比亚乳腺癌的关键决定因素.
- 建议包括提高社区意识,促进乳腺自我检查,并制定有针对性的计划,以减轻乳腺癌日益增长的负担.
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