用外部光束放射治疗治疗局部前列腺癌治疗后的生物化学结果:一个横截面研究
Joseph Daniels1, Kofi Adesi Kyei1,2, Kikelomo Adeola Badejoko-Okunade2,3
1National Centre for Radiotherapy, Oncology and Nuclear Medicine, Korle Bu Teaching Hospital, PO Box KB 369, Korle Bu, Accra, Ghana.
Ecancermedicalscience
|February 28, 2024
概括
外部射线疗法 (EBRT) 在加纳局部性前列腺癌 (CaP) 的生化失败率较低. 对结果的关键预后因素包括阳性活检核,等级组和风险分层.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 绝对放射治疗 (RT) 为局部前列腺癌 (CaP) 提供了长期生存,但生化进展可能需要进一步治疗.
- 前列腺癌患者的生物化学失败 (BCF) 会导致累积的副作用,不便和财务毒性.
- 了解加纳等不同环境中的治疗结果对于全球癌症护理至关重要.
研究的目的:
- 评估局部性前列腺癌患者的临床病理特征和生化结果,这些患者接受了外部光束放射治疗 (EBRT).
- 在加纳人群中确定EBRT后生化失效 (BCF) 的比率.
- 为了确定影响前列腺癌患者接受EBRT的生化结果的预后因素.
主要方法:
- 在2015-2020年间接受EBRT治疗的局部性前列腺癌患者的回顾性分析.
- 数据收集包括社会人口统计,临床数据和血清前列腺特异性抗原 (PSA) 水平.
- 生物化学失败 (BCF) 根据城标准定义 (PSA>2 ng/mL高于最低值).
主要成果:
- 患者的平均年龄为67.6岁;64.8%的初始PSA>20 ng/mL.
- 外部光束放射治疗 (EBRT) 导致生物化学失败 (BCF) 率为13.1%,平均随访时间为31.3个月.
- 阳性核的百分比,等级组和风险分层是生物化学结果的显著预后因素.
结论:
- 外部射线疗法 (EBRT) 在加纳的局部前列腺癌 (CaP) 中表现出低的生化失效率 (BCF).
- 预后因素,如正核百分比,等级组和风险分层,显著影响治疗结果.
- 腹和脱皮是主要的副作用,一些患者在放射治疗后出现症状消失.
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