系统性免疫炎症指数,系统性炎症反应指数和成人牛皮之间的关联:来自NHANES的证据
Rui Ma1,2, Lian Cui1,2, Jiangluyi Cai1,2
1Department of Dermatology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China.
Frontiers in immunology
|February 28, 2024
概括
系统性免疫炎症指数 (SII) 和系统性炎症反应指数 (SIRI) 与美国成年人牛皮风险更高有关. 这些炎症标志物与皮肤状况有显著的关联.
科学领域:
- 生物标志物和炎症的研究
- 皮肤病学 皮肤病学
- 公共卫生 公共卫生
背景情况:
- 牛皮是一种慢性炎症性皮肤疾病.
- 系统免疫炎症指数 (SII) 和系统炎症反应指数 (SIRI) 是炎症的新兴生物标志物.
- 大人的SII,SIRI和牛皮之间的关系需要进一步调查.
研究的目的:
- 检查SII-SIRI模式和个别SII和SIRI水平与美国成年人牛皮的流行率之间的关联.
- 探索这些炎症标志物和牛皮之间的潜在非线性关系.
- 确定SII和牛皮之间的关联可能更强的子组.
主要方法:
- 在国家健康和营养检查调查 (NHANES) (2003-2006,2009-2014) 中利用了美国成年人 (20-80岁) 的数据.
- 雇佣K-意味着对SII和SIRI级别进行集群,并将其分类为低,中,高分组.
- 使用多变量逻辑回归,受限立方线和子组分析来评估关联.
主要成果:
- 较高的SII-SIRI模式与增加的牛皮风险显著相关 (OR=1.40).
- 无论是SII还是SIRI,在高与低组 (OR=1.52对于SII,OR=1.48对于SIRI) 中,都单独显示出与牛皮风险的积极关联.
- 在lnSII/SIRI和牛皮之间观察到非线性关系;在女性,肥胖个体和2型糖尿病患者中,相关性更强.
结论:
- 在美国成年人中,SII-SIRI模式,SII,SIRI和牛皮之间存在积极的联系.
- 这些发现表明SII和SIRI可能是牛皮风险的潜在指标.
- 需要进一步的研究来阐明这些关联.
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