相关实验视频

Updated: Jul 2, 2025

Author Spotlight: Transmitochondrial Cybrid Generation Using Cancer Cell Lines

Author Spotlight: Transmitochondrial Cybrid Generation Using Cancer Cell Lines

Published on: March 17, 2023

在瘤T细胞能量代谢重编程方面的进展

Liu Xuekai¹, Song Yan¹, Chu Jian^2,3,4

¹Department of Clinical Laboratory, Aerospace Center Hospital, Beijing, China.

Frontiers in immunology

|February 28, 2024

概括

对T细胞的代谢重编程是癌症免疫治疗的关键. 了解T细胞能量代谢可以增强对癌症的免疫反应,改善治疗结果.

科学领域:

免疫学免疫学免疫学
癌症生物学癌症生物学
代谢研究研究代谢研究

背景情况:

癌症免疫疗法旨在增强T细胞对瘤的反应.
T细胞能量代谢对于它们的激活,增殖和功能至关重要.
瘤微环境显著影响T细胞代谢.

研究的目的:

审查T细胞代谢重编程用于癌症免疫疗法的当前成就.
引入影响T细胞能量代谢的因素.
总结T细胞能量代谢在增强癌症免疫治疗中的作用.

主要方法:

关于T细胞能量代谢的文献综述.
分析影响T细胞代谢的因素.
在癌症免疫治疗中T细胞代谢的概述.

主要成果:

对T细胞的代谢重编程是癌症免疫治疗中一个有前途的策略.
瘤微环境改变T细胞的能量代谢,导致功能疲.
了解这些代谢变化可以揭示瘤免疫耐受性的机制.

结论:

在T细胞中的能量耗尽导致功能耗尽和癌症免疫逃避.
研究T细胞能量代谢为开发新型免疫治疗策略提供了洞察力.
优化T细胞代谢有望提高癌症治疗效率.

关键词:

在T细胞,T细胞.能量代谢能量代谢免疫微观环境免疫微环境免疫疗法免疫疗法代谢重编程是指代谢重编程.

更多相关视频

Generation of Induced Pluripotent Stem Cells from Human Melanoma Tumor-infiltrating Lymphocytes

Generation of Induced Pluripotent Stem Cells from Human Melanoma Tumor-infiltrating Lymphocytes

Published on: November 11, 2016

Measurement of Mitochondrial Mass and Membrane Potential in Hematopoietic Stem Cells and T-cells by Flow Cytometry

Measurement of Mitochondrial Mass and Membrane Potential in Hematopoietic Stem Cells and T-cells by Flow Cytometry

Published on: December 26, 2019

相关概念视频

Adaptive Mechanisms in Cancer Cells

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

mTOR Signaling and Cancer Progression

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...