循环中的Tfh和Th17正常化与用ofatumumabb治疗的大脑筋疲劳症的改善有关
Xiaodong Song1,2, Yang He1, Yang Huo1
1Department of Neurology, Peking University People's Hospital, Beijing, China.
Frontiers in immunology
|February 28, 2024
概括
乙细胞枯竭疗法 (BCDT) 在肌痛性硬化症 (MG) 患者中使T毛囊辅助细胞 (cTfh) 和T辅助细胞17 (cTh17) 的升高正常化. 这种正常化与临床改善相关,表明这些细胞是治疗点.
科学领域:
- 免疫学 免疫学 免疫学
- 神经免疫学 神经免疫学
- 细胞免疫学 细胞免疫学
背景情况:
- 骨髓灰质炎 (MG) 是一种自身免疫性疾病,影响神经肌肉结节.
- 毛囊T辅助细胞 (cTfh) 和T辅助细胞17 (cTh17) 参与自身免疫病原发生.
- 这些特定的T细胞子集在MG中的作用及其对治疗的反应需要进一步阐明.
研究的目的:
- 研究B细胞枯竭疗法 (BCDT) 对肌痛性骨髓灰质炎 (MG) 患者的循环T毛囊辅助细胞 (cTfh) 和循环T辅助细胞17 (cTh17) 的影响.
- 确定cTfh和cTh17细胞频率的变化与BCDT后的临床改善之间的关系.
- 在BCDT期间分析相关的细胞因子 (IL-6,IL-21,IL-17) 概况.
主要方法:
- 流细胞计用于量化28名MG患者和28名健康对照 (HC) 的cTfh和cTh17细胞频率.
- 测量是在基线和ofatumumab治疗后4周和12周进行的.
- 同时分析了IL-6,IL-21和IL-17的血清水平.
主要成果:
- 与HC相比,MG患者的cTfh和cTh17细胞频率显著更高,与疾病严重程度相关.
- 与ofatumumab的BCDT导致cTfh和cTh17细胞频率显著下降,使它们恢复到正常水平.
- 这些T细胞子集和相关细胞因子 (IL-6,IL-21,IL-17) 的减少与MG临床评分的改善密切相关.
结论:
- cTfh和cTh17细胞的异常扩张是MG免疫病理学的关键特征.
- 在MG患者中,BCDT有效地减少了这些异常T细胞群.
- 在BCDT后cTfh和cTh17细胞的正常化与临床改善相关,将它们确定为MG的潜在治疗标.
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