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塞沃弗兰改变了老年和老化小鼠的血清代谢物,增加了海马体的炎症
Tingting Wang1,2,3, Xia Wu4, Xiaoli Zhao2,3
1Department of Anesthesiology, Anesthesiology Research Institute, The First Affiliated Hospital of Fujian Medical University, Fuzhou, People's Republic of China.
Journal of inflammation research
|February 28, 2024
概括
塞沃弗兰麻醉剂改变血清代谢物并增加老年患者和老年小鼠的海马体炎症,导致术后认知功能障碍 (POCD). 这项研究通过检查代谢物变化和神经炎症来探索POCD的发病过程.
科学领域:
- 神经科学是一个神经科学.
- 麻醉学 麻醉学
- 代谢学 代谢学 代谢学
- 文字转录学 (Transcriptomics) 是一个学科.
背景情况:
- 手术后认知功能障碍 (POCD) 是麻醉后的常见并发症,特别是在老年人中.
- 波多野结衣症的潜在神经机制尚未完全理解.
- 调查麻醉剂对认知功能的影响对于患者安全至关重要.
研究的目的:
- 评估sevoflurane对老年患者和老化小鼠血清代谢物和海马体基因表达的影响.
- 为了探索sevoflurane诱导的POCD的发病原因.
- 确定POCD潜在的生物标志物和治疗点.
主要方法:
- 从老年患者收集了血清样本,在sevoflurane麻醉之前和之后.
- 用sevoflurane麻醉老年小鼠和收集的血清和海马体组织.
- 利用代谢学和转录学分析来识别差异性代谢物和基因表达变化.
- 通过使用BV2微质细胞研究伊沙丁在神经炎症中的作用.
主要成果:
- 塞沃兰麻醉激活了炎症通路,增加了海马星球细胞和微质细胞的存在.
- 鉴定了12种不同血清代谢物,这些代谢物在人类和小鼠中都是常见的.
- 在sevoflurane麻醉后观察到异氨酸水平显著下降,与微质激活和促炎基因表达有关.
结论:
- 在老年人和老年老鼠中,sevoflurane 麻醉会诱导血清代谢物的变化.
- 这些代谢变化有助于增加海马神经炎症.
- 这些发现表明,sevoflurane诱导的POCD的潜在机制涉及代谢失调和神经炎症.
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