在接受化疗的上皮卵巢癌患者的身体组成和蛋白质摄入量的动态变化:一项初步研究
Nurul Ratna M Manikam1, Andrijono Andrijono2, Fiastuti Witjaksono1
1Department of Nutrition, Faculty of Medicine Universitas Indonesia- Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
Asian Pacific journal of cancer prevention : APJCP
|February 28, 2024
概括
接受化疗的卵巢癌患者经历了身体组成的变化. 低体重患者摄入较高的蛋白质显示骨肌肉质量和无脂肪质量有所改善,与超重患者不同.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 身体组成分析 身体成分分析
背景情况:
- 卵巢癌患者通常营养状况不佳,影响预后.
- 身体成分 (BC) 是卵巢癌的一个关键预后指标.
- 骨肌肉质量 (SMM) 和无脂肪质量 (FFM) 预测生存和住院.
研究的目的:
- 在化疗期间记录卵巢癌患者的身体组成变化.
- 为了将这些身体组成的变化与营养摄入相关联.
主要方法:
- 在12名III期卵巢癌患者中使用生物电阻分析评估身体组成.
- 通过24小时回忆来监测营养摄入量 (能量,蛋白质,脂肪,碳水化合物).
- 评估了基线,第三和第六次化疗周期的变化.
主要成果:
- 体重不足患者的体重和整体BC参数显著增加.
- 蛋白质摄入量大于1.2g/kg体重,导致体重不足患者的SMM增加.
- 超重/肥胖患者的FFM显著下降,归因于体内水分减少.
结论:
- 在卵巢癌患者的化疗期间,身体成分在动态变化.
- 体重不足的患者表现出更明显的FFM增强.
- 改善的相角,SMM和FFM与体重不足患者的蛋白质摄入量>1.2g/kg的BW有关.
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