社区查高风险人乳头瘤病毒感染,使用自取样和"护理点"测试
Shilpa Panta1, Shalini Rajaram2, Ayush Heda2
1Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, Rishikesh, India.
Asian Pacific journal of cancer prevention : APJCP
|February 28, 2024
概括
使用自行收集的阴道样本进行高风险人类乳头瘤病毒 (HR-HPV) 测试,发现患病率为4.6%,60%的阳性病例是HPV 16/18. 这项研究证实了在社区中对照料点HR-HPV测试的可行性和可接受性.
科学领域:
- 在瘤学瘤学.
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- 人类乳头瘤病毒 (HPV) 类型16和18是宫前入侵性和入侵性病变的主要驱动因素,占病例的70-80%.
- 早期检测和预防策略对于管理宫癌负担至关重要.
研究的目的:
- 在自收集的阴道样本中确定高风险HPV (HR-HPV) 类型16和18的患病率.
- 评估HR-HPV检测实时微PCR在社区环境中的可接受性和可行性.
- 为了评估女性的舒适度和愿意性,建议女性进行HPV检测的自我抽样.
主要方法:
- 来自印度Uttarakhand州一个半城市地区的975名女性 (30-65岁) 参与了使用自我抽样的队列.
- 实时微型PCR用于初始HR-HPV基因型定型 (16/31和18/45),结果可在一个小时内获得.
- 用标准RT-PCR对特定HR-HPV类型 (16,18) 和其他高风险基因型进行验证. 可接受性是通过利克特尺度来衡量的.
主要成果:
- 通过实时微型PCR检测到的HR-HPV (16/31,18/45) 的总体患病率为4.6% (975名女性中有45名).
- 在阳性样本中,60%通过RT-PCR确认为HR-HPV 16和18阳性.
- 自我采样显示了很高的可接受性:96.7%的人认为该程序"非常令人满意",94.1%的人"非常舒适",88.5%的人会推它.
结论:
- 在社区环境中进行有限的基因型鉴定的HR-HPV测试是可行的,并且产生了4.6%的显著患病率,其中HPV 16/18占主导地位.
- 对于女性来说,HR-HPV检测的自我抽样是非常可接受的,这表明它有可能在宫癌查计划中得到广泛实施.
- 在社区环境中使用实时微型PCR的临床检测提供了一种快速有效的方法来识别有风险的妇女.
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