血清样本中总有效的异性雌激素负担和子宫内膜癌的风险在西班牙全屏幕病例对照研究中
Laura Costas1,2,3, Jon Frias-Gomez1,2,3,4, Francisco M Peinado5,6
1Cancer Epidemiology Research Programme, Catalan Institute of Oncology, Hospitalet de Llobregat, Barcelona, Spain.
Environmental health perspectives
|February 28, 2024
概括
作为异雌激素的环境污染物可能会影响子宫内膜癌的风险. 这项研究发现了反转的U风险趋势,表明中度暴露水平与风险增加有关,而较高水平没有显著的关联.
科学领域:
- 环境健康 环境健康
- 内分泌学 在内分泌学.
- 癌症研究 癌症研究
背景情况:
- 子宫内膜癌是荷尔蒙依赖的,雌激素起着关键作用.
- 具有异性雌激素活性的环境污染物对子宫内膜癌的影响尚不清楚.
研究的目的:
- 评估血清和子宫内膜癌症风险中的 Estrogen 混合物的联合雌激素活性之间的关系.
主要方法:
- 分析了来自156例子宫内膜癌患者和150例对照患者的血清样本.
- 使用化学提取,HPLC和E-SCREEN生物试验评估了总有效的异性雌激素负担 (TEXB).
主要成果:
- 病例和对照之间的TEXB水平中位数没有显著差异.
- 观察到一个反转的U风险趋势:增加的风险与中度暴露类别相关,但不是最高的风险.
- 个别的质污染物一般没有与TEXB或癌症风险的关联.
结论:
- 血清总的异性雌激素负担显示了与子宫内膜癌症风险的反转-U关系.
- 用人体样本进行体外生物测试为化学混合物对健康的影响提供了新的见解.
- 这些发现与公众健康和化学法规有关,这些法规涉及异雌激素化合物.
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