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Updated: Jul 2, 2025

A Fluorogenic Peptide Cleavage Assay to Screen for Proteolytic Activity: Applications for coronavirus spike protein activation
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病毒细胞适应的SARS-CoV-2菌株通过氨酸介导的高效尖峰裂变增加了病毒生长

Shohei Minami1, Tomohiro Kotaki1, Yusuke Sakai2

  • 1Department of Virology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.

Microbiology spectrum
|February 28, 2024
PubMed
概括

在SARS-CoV-2尖端蛋白的突变增强病毒生长和furin裂变,导致减弱的致病性. 这种适应菌株显示出开发针对SARS-CoV-2变种的有效,低成本的非活化疫苗的潜力.

关键词:
感染的感染感染.病原性 病原性 病原性严重急性呼吸系统综合征病毒-2 (SARS-CoV-2)尖刺 (S) 蛋白质是什么病毒复制病毒复制

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