生殖器慢性移植对宿主疾病:一个未满足的需求,需要训练有素的妇科医生
M Á Martínez-Maestre1, C Castelo-Branco2, A M Calderón1
1Department of Gynecology, Virgen del Rocío University Hospital, Seville, Spain.
Climacteric : the journal of the International Menopause Society
|February 28, 2024
概括
慢性移植对宿主疾病 (cGvHD) 影响了20%的女性在异质造血干细胞移植 (alloHSCT) 后,导致生殖器症状. 早期的妇科评估对于管理生殖器cGvHD和改善患者结果至关重要.
科学领域:
- 血液学 血液学 血液学
- 妇科 妇科 妇科 妇科
- 在瘤学瘤学.
背景情况:
- 更年期和慢性移植对宿主疾病 (cGvHD) 是所有原性造血干细胞移植 (alloHSCT) 后的主要疾病.
- 在cGvHD中,生殖器的参与会导致性功能障碍和局部症状,严重影响女性的生活质量.
- 了解生殖器cGvHD的患病率和临床特征对于患者护理至关重要.
研究的目的:
- 为了确定在接受allHSCT的女性中生殖器cGvHD的流行率.
- 描述生殖器cGvHD的临床特征,症状和症状.
- 调查生殖器cGvHD与死亡率之间的关联.
主要方法:
- 追溯横截面观察性研究,包括85名女性后alloHSCT.
- 由经过培训的专家进行妇科评估.
- 评估使用塞万提斯简体表格尺度和通过女性性功能指数评估性功能的生活质量.
主要成果:
- 17名女性 (20%) 确诊了生殖器cGvHD.
- 常见的症状包括 vulvovaginal 干燥 (42.2%) 和失精 (29.4%). 红斑/红斑斑是最常见的症状 (52.9%).
- 与没有 (8.8%,p=0.012) 的患者相比,患有生殖器cGvHD的患者的死亡率明显高 (29.4%).
结论:
- 生殖器cGvHD影响了后alloHSCT妇女的显著比例.
- 早期的妇科评估可以识别轻度病例,促进及时管理.
- 及时诊断和管理生殖器cGvHD可以改善患者的结果,并可能降低死亡率.
相关概念视频
Sexually Transmitted Infections
306
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
306
Tissue Transplantation
366
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
366


