进化速率共变是共同功能相互作用的可靠预测指标,但不一定是物理相互作用
Jordan Little1, Maria Chikina2, Nathan L Clark1,3
1Department of Human Genetics, University of Utah, Salt Lake City, United States.
eLife
|February 28, 2024
概括
进化速率共变 (ERC) 衡量了蛋白质进化速率的相关性,表明了功能联系. 这项研究发现,物理蛋白相互作用对ERC的影响很弱,共享的选择性压力是一个更强大的驱动因素.
科学领域:
- 进化生物学是进化的生物学.
- 基因组学就是基因组学.
- 生物信息学是一种生物信息学.
背景情况:
- 同功能的蛋白质随着时间的推移表现出相关的进化速率.
- 进化速率共变 (ERC) 量化了这一对应关系在家族遗传树上,以推断基因网络.
- 相关率的假设包括补偿性共同进化和共享的选择性压力.
研究的目的:
- 调查物理蛋白界面上的补偿突变是否对ERC信号有可测量的贡献.
- 为了区分来自物理相互作用的ERC信号与其他进化力.
主要方法:
- 在复合体内的物理相互作用和非相互作用蛋白质域之间对ERC信号的比较分析.
- 检查整个家族遗传学分支的进化速率.
主要成果:
- 在物理蛋白相互作用和高ERC信号之间没有发现一致的,可概括的关系.
- 在一些综合体中观察到物理相互作用对ERC信号的微弱但可检测的贡献.
- 似乎ERC信号受到对蛋白质作为一个整体起作用的选择性压力的影响更大.
结论:
- 由物理相互作用驱动的共同进化在ERC信号中起到较小的作用.
- 共享的选择性压力和整体蛋白质功能的维持可能是驱动观察到的进化速率共变的主要因素.
相关概念视频
Speciation Rates
21.2K
Overview
21.2K
Evolutionary Relationships through Genome Comparisons
5.7K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
5.7K
Gene Evolution - Fast or Slow?
7.1K
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
In contrast, regions which code...
7.1K
Convergent Evolution
27.7K
Evolution shapes the features of organisms over time, ensuring that they are suited for the environments in which they live. Sometimes, selection pressure leads to the rise of similar but unrelated adaptations in organisms with no recent common ancestors, a process known as convergent evolution.
27.7K
Evolutionary Psychology
264
Evolutionary psychology explores the origins of human behavior and mental processes by framing them within the context of natural selection, a theory famously propounded by Charles Darwin. This field asserts that many behaviors common across human societies — ranging from instinctive fear reactions to complex social interactions — arose as evolutionary adaptations. These adaptations enhanced the survival and reproductive success of our ancestors, thereby becoming embedded in the...
264
Mutation, Gene Flow, and Genetic Drift
58.4K
In a population that is not at Hardy-Weinberg equilibrium, the frequency of alleles changes over time. Therefore, any deviations from the five conditions of Hardy-Weinberg equilibrium can alter the genetic variation of a given population. Conditions that change the genetic variability of a population include mutations, natural selection, non-random mating, gene flow, and genetic drift (small population size).
58.4K


