产后的寨卡病毒感染导致神经位内的形态和细胞变化
Jéssica C C G Ferreira1, Raissa R Christoff1, Tailene Rabello1
1Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21941-590, Brazil.
Disease models & mechanisms
|February 28, 2024
概括
新生儿寨卡病毒感染会损害新生小鼠发育中的牙状,导致细胞死亡和改变大脑结构. 这项研究揭示了先天性寨卡综合征.
科学领域:
- 神经科学是一个神经科学.
- 病毒学 病毒学
- 发展生物学 发展生物学
背景情况:
- 在2016年宣布的寨卡病毒流行病,与小头症有关.
- 产前寨卡病毒感染导致胎儿神经干细胞损伤和先天性寨卡综合征.
- 对新生儿寨卡病毒感染对新生儿神经系统的影响的理解有限.
研究的目的:
- 研究新生儿寨卡病毒感染对小鼠发育中的牙状环的影响.
- 阐明导致先天性寨卡综合征的神经特征的细胞机制.
主要方法:
- 在出生时 (出生后的第0天) 给野生型小鼠注射寨卡病毒.
- 分析牙状的发育,神经发生,细胞增殖,细胞死亡和反应性化.
- 评估产后牙状的体积变化.
主要成果:
- 寨卡病毒感染损害了牙状圈内的神经性区域.
- 观察到反应性化和细胞死亡的增加.
- 观察到细胞增殖减少和牙状的体积特征发生变化.
- 新生儿对寨卡病毒的暴露对牙状的亚粒状区域有害.
结论:
- 新生儿寨卡病毒感染对小鼠的牙状发育产生不利影响.
- 这些发现提供了关于先天性寨卡综合征神经表现的细胞机制的见解.
- 强调发育中的大脑在出生后对寨卡病毒感染的脆弱性.
相关概念视频
01:30Neurulation
41.9K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
41.9K
01:15Neurogenesis and Regeneration of Nervous Tissue
776
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
776