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牛奶和小麦挑战期间最初症状出现的时间:一项回顾性研究

Noriyuki Yanagida^1,2, Takanori Minoura², Sakura Sato¹

¹Department of Allergy, Clinical Research Center for Allergy and Rheumatology, NHO Sagamihara National Hospital, Kanagawa, Japan.

Immunity, inflammation and disease

|February 28, 2024

概括

在口服食品挑战 (OFC) 中,对小麦的过敏反应比牛奶过敏晚出现. 这项研究建议多剂量小麦OFC的间隔较长,以确保患者的安全.

科学领域:

儿科过敏和免疫学
临床营养学临床营养学
食品科学食品科学食品科学

背景情况:

口服食物挑战 (OFC) 对于诊断食物过敏至关重要.
以前的研究表明,牛奶过敏比蛋过敏更快地表现出症状.
在OFC期间对小麦的过敏反应的时间需要进一步调查.

研究的目的:

为了比较牛奶和小麦过敏之间的过敏反应的发病时间,在OFC期间.
为小麦OFCs的安全协议提供见解.

主要方法:

2009年至2023年间从牛奶和小麦的OFC进行的回顾性数据收集.
在被诊断为牛奶和小麦过敏的儿童中,症状发病时间的比较.
使用标准化食品矩阵对单剂量OFC进行分析.

主要成果:

牛奶过敏的症状开始时间中位数为20分钟,小麦过敏的症状开始时间为53分钟 (p=0.006).
具有积极牛奶挑战的儿童的平均年龄为1.4岁,而小麦过敏的儿童的平均年龄为2.8岁.
该研究涉及25名患有牛奶过敏的儿童和13名患有小麦过敏的儿童.

结论:

在OFCs期间,对小麦的过敏反应明显晚于对牛奶的过敏反应.
对于多剂量的小麦OFC,建议剂量间隔超过60分钟.
这些发现提高了OFC对小麦过敏诊断程序的安全性.

关键词:

孩子孩子孩子孩子孩子孩子食物过敏食物过敏最初的症状是最初的症状.牛奶牛奶牛奶牛奶口服食物挑战口服食物挑战时间时间时间时间时间.小麦小麦小麦小麦小麦小麦小麦.

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