体重指数对CRSwNP的影响扩展到病态内型和复发
1Department of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
患有鼻息息肉 (CRSwNP) 慢性鼻炎的患者体质指数 (BMI) 升高与独特的免疫学特征和复发率增加有关. 传统的复发预测剂在超重/肥胖的CRSwNP个体中效果较差.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 免疫学 免疫学 免疫学
- 肥胖问题研究研究
背景情况:
- 体重指数 (BMI) 升高是慢性鼻炎与鼻息肉 (CRSwNP) 皮质类固醇不敏感的一个已知的因素.
- 了解BMI对CRSwNP免疫内型和疾病复发的影响至关重要.
研究的目的:
- 研究高BMI对CRSwNP.的免疫内型的影响.
- 为了确定BMI和CRSwNP的复发之间的关系.
主要方法:
- 325名接受FESS的CRSwNP患者根据BMI进行了分层.
- 组织学和免疫组织化学染色被用来评估炎症模式.
- 多变量后勤回归和ROC曲线分析了BMI组中的复发预测因素.
主要成果:
- 超重/肥胖的CRSwNP患者 (26.15%) 呈现出更高的症状负担和独特的内型,其中有氨基/中性质细胞占主导地位和2/3型炎症.
- 超重/肥胖个体的复发率更高.
- 体重指数是复发的独立预测指标,但传统参数显示该组预测能力较差.
结论:
- 超重/肥胖的CRSwNP代表了一个独特的表型和内型.
- 目前用于预测复发的生物标志物对于超重/肥胖CRSwNP患者来说不足.
- 需要新的生物标志物来预测超重/肥胖CRSwNP的复发.
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