工程纳米系统用于通过皮肤输送抗高血压药物
Mingliang Fan1, Wengang Liu1, Liangfeng Zhao1
1School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China.
Pharmaceutical development and technology
|February 28, 2024
概括
与口服药物相比,纳米载体可以改善抗高血压药物的通过皮肤传递,提高患者的服药性,减少副作用. 本综述探讨了用于高血压治疗的纳米系统的进展.
科学领域:
- 药理学和药物输送 药理学和药物输送
- 纳米技术在医学中的应用
- 心血管治疗学心血管治疗学
背景情况:
- 高血压管理需要持续的抗高血压治疗,通常涉及口服药物,如利尿剂,β-阻断剂,管阻断剂,ARB和ACE抑制剂.
- 口服抗高血压药物面临的局限性包括全身副作用和第一通肝新陈代谢,表明需要改进的输送系统.
- 使用纳米载体的透皮药物递送系统为提高药物疗效和患者服药性提供了一个有希望的替代方案.
研究的目的:
- 审查目前关于以纳米系统为基础的超皮药物输送高血压的文献.
- 为突出工程跨皮传递纳米系统的抗高血压剂的最新进展.
- 讨论这个领域的挑战和未来前景.
主要方法:
- 对同行评审文章和研究论文的文献评论.
- 综合各种纳米载体类型的信息,用于通过皮肤递送药物.
- 对通过透皮途径研究抗高血压药物的疗效和安全性的研究进行分析.
主要成果:
- 纳米系统显示了增强皮肤透和针对性输送抗高血压药物的潜力.
- 透皮纳米系统可以减少系统性副作用,并与口服配方相比,改善患者的坚持.
- 目前正在探索各种纳米载体平台,包括脂质体,纳米颗粒和纳米乳液,用于跨皮抗高血压疗法.
结论:
- 基于纳米系统的通过皮肤递送具有更有效,更为患者友好的高血压管理的重大前景.
- 需要进一步的研究和开发,以克服这些先进的药物输送系统的扩展和临床转化方面的挑战.
- 通过皮肤传递纳米系统的工程代表了未来心血管药物治疗创新的关键领域.
相关概念视频
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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
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01:18Drug Delivery: Enteral Route
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01:16Drug Delivery: Overview
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01:15Non-Oral Extravascular Drug Absorption Routes
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