相关实验视频

Updated: Jul 2, 2025

Accessing the Cytotoxicity and Cell Response to Biomaterials

Accessing the Cytotoxicity and Cell Response to Biomaterials

Published on: July 8, 2021

发现了对臭性角质囊的代谢物生物标志物

Shuai Wang^1,2, Liyuan Yu¹, Lin Chen¹

¹Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Nanjing, 210008, Jiangsu, China.

Metabolomics : Official journal of the Metabolomic Society

|February 28, 2024

概括

血清代谢分析识别了10个关键代谢物,用于诊断臭性角囊 (OKC). 这一突破为检测OKC提供了一个高度准确的,非侵入性的方法,有助于理解它们的病原性.

科学领域:

生物化学生物化学
在瘤学瘤学.
代谢学代谢学代谢学

背景情况:

牙生囊 (OKC) 的特点是局部的侵略性和高的复发率.
对OKCs的潜在病原性仍然不完全理解.
确定可靠的生物标志物对于早期诊断和管理至关重要.

研究的目的:

为了研究患有臭性角囊 (OKC) 的患者的血清代谢概况.
为了确定OKC诊断的潜在血清代谢生物标志物.
探索代谢学在理解OKC病变发生过程中的作用.

主要方法:

来自22名OKC患者和20名健康对照者的血清样本使用气体染色体质谱法 (GC-MS) 进行了分析.
分析了代谢数据,以确定失调的代谢物.
拉索回归和ROC曲线分析用于生物标志物选择和诊断模型开发.

主要成果:

总共有73种代谢物被检测到,其中24种在OKC患者中被发现是失调的.
在OKC组中,四种代谢物显示出显著的上调.
一个由10种代谢物组成的诊断小组实现了OKC诊断100%的灵敏度和100%的特异性 (AUC=1.00).

结论:

这项研究是对OKC患者血清代谢概况和生物标志物的首次基于GC-MS的研究.
已识别的代谢生物标志物显示了OKC的高诊断准确性.
这些发现有助于更深入地了解OKC病原体,并为新的诊断策略提供潜力.

关键词:

生物标志物生物标志物牙发生性角囊.血清代谢概况分析没有针对性的代谢组分.

更多相关视频

Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies

Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies

Published on: August 11, 2023

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Published on: February 28, 2019

相关概念视频

MALDI-TOF Mass Spectrometry

MALDI-TOF Mass Spectrometry

Mass spectrometry is a powerful characterization technique that can identify and separate a wide variety of compounds ranging from chemical to biological entities, based on their mass-to-charge ratio (m/z). The instruments that allow this detection, known as mass spectrometers, have three components: an ion source, a mass analyzer, and a detector. These spectrometers differ based on the nature of their ion source and analyzers.
Matrix-assisted laser desorption ionization (MALDI) is a commonly...