疹疹复发:对文献的叙述性审查
Raunak Parikh1, O'Mareen Spence2, Nikolaos Giannelos3
1Global Medical Affairs, Shingrix, GSK Wavre, Av. Fleming 20, Wavre, Belgium. raunak.p.parikh@gsk.com.
Dermatology and therapy
|February 28, 2024
概括
患有疹 (HZ) 或带状疹的个人面临复发的风险,增加疾病的风险.
科学领域:
- 传染性疾病 传染性疾病
- 流行病学 流行病学
- 免疫学 免疫学 免疫学
背景情况:
- 带状疹 (HZ) 或带状疹是一种痛苦的疹病毒的重新激活,造成严重的医疗负担.
- 肝炎可以导致神经病痛,后神经疼痛,视力丧失和中风等衰弱症状,特别是在免疫受损的个体中.
- 在现有的文献中,没有全面审查HZ复发的负担.
研究的目的:
- 对疹复发的发病率,风险因素和临床特征进行全面的文献审查.
- 评估HZ复发对整体疾病负担的影响.
主要方法:
- 对2003年1月1日至2023年2月2日期间发表的文献进行了PubMed搜索.
- 搜索的重点是研究HZ复发的发病率,风险因素和临床特征的研究.
主要成果:
- 肝炎复发的发生率差异很大:在一般人群中为1.2-9.6%,在免疫受损个体中为0.0-18.2%.
- 每1000人年发生率为1.7-16.6一般人群和17.0-55免疫功能低下个体.
- 复发的危险因素包括免疫功能低下,女性性别,家族病史,糖尿病,持续性疼痛和疹眼科.
结论:
- 个人在初始发作后仍然存在HZ复发的风险,这有助于整体疾病负担.
- 对于HZ的国家疫苗接种建议应该包括免疫能力和免疫力低下的个人,他们有HZ病史.
- 疫苗接种是预防HCZ及其复发的关键策略.
相关概念视频
Viral Recombination
22.3K
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
22.3K
Vaccinations
44.1K
Overview
44.1K
Immunological Memory
12.3K
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
12.3K
Infectious Diseases and Their Occurrence
94
Infectious diseases appear in populations through various transmission patterns, influenced by pathogen characteristics, population immunity, environmental conditions, and social behavior. Understanding these patterns is essential for effective public health surveillance and intervention. These categories—sporadic, outbreak, epidemic, pandemic, and endemic—help frame the nature and scope of disease events.Sporadic diseases occur irregularly and infrequently, without a predictable...
94
Cytomegalovirus Disease
102
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
102
Viral Hepatitis I: Introduction
25
Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion...
25


