时间定制的药物输送系统:最近的进展和未来的方向
Christine T Butler1, Aoife M Rodgers2, Annie M Curtis3
1Curtis Clock Laboratory, School of Pharmacy and Biomolecular Sciences and Tissue Engineering Research Group (TERG), Royal College of Surgeons in Ireland RCSI, Dublin, Ireland.
Drug delivery and translational research
|February 28, 2024
概括
循环节律调节身体的过程,定制药物输送系统 (DDS) 将药物释放与这些内部时钟保持一致. 这种方法优化了药物的疗效,并最大限度地减少了副作用,以获得更好的健康结果.
科学领域:
- 时间生物学 时间生物学
- 药理学 药理学是指药理学的学科.
- 免疫学 免疫学 免疫学
背景情况:
- 循环节律由上神核 (SCN) 控制,同步生物过程.
- 外围时钟是通过外部线索同步的,主要是光/黑暗周期.
- 时间量身定制的药物递送系统 (DDS) 利用这些节奏进行定时的药物释放.
研究的目的:
- 为了回顾昼夜节律的生物学.
- 为提供关于定制时间DDS的当前研究的概述.
- 专注于免疫学应用和疫苗接种战略.
主要方法:
- 关于昼夜生物学的文学评论.
- 对现有的定制时间DDS研究进行分析.
- 在各种医疗条件下探索DDS应用.
主要成果:
- 定制的DDS显示了提高药物的有效性和减少副作用的潜力.
- 在喘,高血压和癌症中探索应用.
- 新兴的重点是免疫学应用和疫苗接种.
结论:
- 定制的DDS提供了一种有希望的方法来优化治疗结果.
- 需要进一步的研究来应对临床翻译的挑战.
- 有潜力提高患者的遵从性和治疗效果.
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