耳性脑膜炎是多么常见的? 在瑞典南部进行了18年的回顾性研究
Nora Bjar1, Ann Hermansson2, Marie Gisselsson-Solen3
1Vårdcentralen Lunden, Ystadgatan 53c, 214 44, Malmö, Sweden.
Infection
|February 28, 2024
概括
急性中耳炎 (AOM) 是细菌性脑膜炎的重要原因,特别是在成年人中. 虽然结合性肺炎球菌疫苗 (PCV) 减少了儿童病例,但成年人脑膜炎发病率似乎有所上升.
科学领域:
- 流行病学 流行病学
- 传染性疾病 传染性疾病
- 疫苗学 疫苗学 疫苗学
背景情况:
- 细菌性脑膜炎是急性中耳炎 (AOM) 的严重并发症,但其确切的贡献尚不清楚.
- 了解AOM和脑膜炎之间的联系对于公共卫生战略至关重要.
研究的目的:
- 确定由AOM引起的脑膜炎病例的比例.
- 为了比较风险因素,病原体和otogenic与non-otogenic脑膜炎的结果.
- 分析结合性肺炎球菌疫苗 (PCV) 引入后细菌性脑膜炎发生率的趋势.
主要方法:
- 对瑞典南部 (2000-2017年) 细菌性脑膜炎患者医疗病历的回顾性审查.
- 使用耳视镜和/或成像数据计算耳性脑膜炎比例和年度发病率.
主要成果:
- 31%的细菌性脑膜炎病例与AOM有关,因年龄而异 (6%在青少年中,40%在成人中).
- 引入PCV大大减少了2岁以下儿童 (23%至1%) 的脑膜炎.
- 成年人脑膜炎的发病率显示PCV后增加,除了青少年 (*N. meningitidis*) 外, *S. pneumoniae*占主导地位.
结论:
- 急性中耳炎是不同年龄段的细菌性脑膜炎的重要原因.
- 在预防幼儿脑膜炎方面,PCV非常有效.
- 在成年人中肺炎球菌脑膜炎的发病率增加需要进一步调查.
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